Department of Chemistry, Faculty of Science, University of Birjand, Birjand, Southern Khorasan, Iran.
Department of Oral Medicine, Oral and Dental Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
BMC Res Notes. 2020 Jun 17;13(1):294. doi: 10.1186/s13104-020-05135-w.
β2 microglobulin, as a biomarker, is used for the diagnosis of oral malignant and pre-malignant lesions. The components of the microglobulin system can directly or indirectly help grow and develop tumors. The present study aims to compare beta-2 microglobulin levels in patients with lichen planus of the esophagus, oral squamous cell carcinoma, and healthy individuals. Further, it evaluated the salivary β2-microglobulin level in malignant and pre-malignant lesions. Oral lichen planus (OLP) is a chronic skin-mucus disorder. Of the total 75 patients referred to Oral Medicine at Dentistry School of Zahedan University of Medical Sciences, 25 were healthy and 25 had oral lichen planus (OLP) and the rest had squamous cell carcinoma (SCC). To collect the saliva samples, unstimulated spitting was used. They were collected between 9 and 12 a.m. Salivary beta2 microglobulin was recorded based on the factory instructions by ELISA optical density method with 450 nm wavelength for each sample. The data were analyzed using descriptive, Kruskal-Wallis and Mann-Whitney and Pearson's correlation coefficient (SPSS 21).
The salivary β2 microglobulin level in patients with squamous cell carcinoma (SCC) and oral lichen plan (OLP) is significantly higher than that in healthy group. Thus, this index is used for assessing early malignant transformation and oral pre-malignant lesion.
β2 微球蛋白作为一种生物标志物，用于诊断口腔恶性和癌前病变。微球蛋白系统的成分可以直接或间接地帮助肿瘤生长和发展。本研究旨在比较食管扁平苔藓、口腔鳞状细胞癌患者和健康个体的β2 微球蛋白水平。进一步评估恶性和癌前病变患者的唾液β2-微球蛋白水平。口腔扁平苔藓（OLP）是一种慢性皮肤-黏膜疾病。在被转诊到扎黑丹医科大学牙科学院口腔医学的 75 名患者中，有 25 名健康，25 名患有口腔扁平苔藓（OLP），其余的患有鳞状细胞癌（SCC）。为了收集唾液样本，使用了非刺激性的吐口水。它们在上午 9 点至 12 点之间采集。根据 ELISA 光密度法的工厂说明，用 450nm 波长记录唾液β2 微球蛋白，每个样本一个。使用描述性、Kruskal-Wallis 和 Mann-Whitney 以及 Pearson 相关系数（SPSS 21）分析数据。
鳞状细胞癌（SCC）和口腔扁平苔藓（OLP）患者的唾液β2 微球蛋白水平明显高于健康组。因此，该指标可用于评估早期恶性转化和口腔癌前病变。
