Zentrum für Molekulare Biologie der Universität Heidelberg, DKFZ-ZMBH, Heidelberg D-69120, Germany.
Annu Rev Biochem. 2013;82:357-85. doi: 10.1146/annurev-biochem-061909-093311.
Posttranslational modification with small ubiquitin-related modifier (SUMO) proteins is now established as one of the key regulatory protein modifications in eukaryotic cells. Hundreds of proteins involved in processes such as chromatin organization, transcription, DNA repair, macromolecular assembly, protein homeostasis, trafficking, and signal transduction are subject to reversible sumoylation. Hence, it is not surprising that disease links are beginning to emerge and that interference with sumoylation is being considered for intervention. Here, we summarize basic mechanisms and highlight recent developments in the physiology of sumoylation.
泛素相关修饰蛋白（SUMO）的翻译后修饰现已成为真核细胞中关键的调控蛋白修饰方式之一。有数百种参与染色质组织、转录、DNA 修复、大分子组装、蛋白质稳态、运输和信号转导等过程的蛋白质可发生可逆 SUMO 化。因此，出现与疾病相关的联系也就不足为奇了，而且 SUMO 化的干扰也开始被考虑用于干预。在这里，我们总结了 SUMO 化的基本机制，并强调了其在生理学方面的最新进展。
