Centre for Dietetics Research (C-DIET-R), School of Human Movement Studies, Connell Building, The University of Queensland, Brisbane, Queensland, Australia.
Can J Physiol Pharmacol. 2013 Jun;91(6):496-501. doi: 10.1139/cjpp-2012-0436. Epub 2013 Mar 11.
There has been substantial recent interest in using vitamin D to improve insulin sensitivity and preventing/delaying diabetes in those at risk. There is little consensus on the physiological mechanisms and whether the association is direct or indirect through enhanced production of insulin-sensitising chemicals, including adiponectin. We examined cross-sectional associations between serum 25-hydroxyvitamin D (25(OH)D) and insulin sensitivity (Matsuda index), parathyroid hormone (PTH), waist circumference, body mass index (BMI), triglycerides (TG), total and high molecular weight (HMW) adiponectin, HMW : total adiponectin ratio (HMW : total adiponectin), and total cholesterol : HDL cholesterol ratio (TC:HDL cholesterol) in 137 Caucasian adults of mean age 43.3 ± 8.3 years and BMI 38.8 ± 6.9 kg/m(2). Total adiponectin (standardised β = 0.446; p < 0.001), waist circumference (standardised β = -0.216; p < 0.05), BMI (standardised β = -0.212; p < 0.05), and age (standardised β = -0.298; p < 0.001) were independently associated with insulin sensitivity. Serum 25(OH)D (standardised β = 0.114; p = 0.164) was not associated with insulin sensitivity, total or HMW adiponectin, HMW : total adiponectin, or lipids. Our results provide the novel finding that 25(OH)D is not associated with HMW adiponectin or HMW : total adiponectin in nondiabetic, obese adults and support the lack of association between 25(OH)D and lipids noted by others in similar groups of patients.
最近，人们对使用维生素 D 来提高胰岛素敏感性、预防/延缓高危人群发生糖尿病产生了浓厚的兴趣。然而，对于其生理机制以及这种关联是通过增强胰岛素敏化化学物质（包括脂联素）的产生而直接或间接发生的，目前尚未达成共识。我们检测了 137 名白种成年人的血清 25-羟维生素 D（25（OH）D）与胰岛素敏感性（Matsuda 指数）、甲状旁腺激素（PTH）、腰围、体重指数（BMI）、甘油三酯（TG）、总和高分子量（HMW）脂联素、HMW:总脂联素比值（HMW:总脂联素）以及总胆固醇与高密度脂蛋白胆固醇比值（TC:HDL 胆固醇）之间的横断面相关性。这些成年人的平均年龄为 43.3±8.3 岁，BMI 为 38.8±6.9kg/m²。总脂联素（标准化β=0.446；p＜0.001）、腰围（标准化β=-0.216；p＜0.05）、BMI（标准化β=-0.212；p＜0.05）和年龄（标准化β=-0.298；p＜0.001）与胰岛素敏感性独立相关。血清 25（OH）D（标准化β=0.114；p=0.164）与胰岛素敏感性、总脂联素或 HMW 脂联素、HMW:总脂联素或血脂无关。我们的研究结果提供了一个新的发现，即 25（OH）D 与非糖尿病肥胖成年人的 HMW 脂联素或 HMW:总脂联素无关，并支持其他人在类似的患者群体中观察到的 25（OH）D 与血脂之间缺乏关联的结论。
