UCD Centre for Food Safety, School of Public Health, Physiotherapy, & Population Science, UCD Centre for Molecular Innovation & Drug Discovery, University College Dublin, Belfield, Dublin, Ireland.
Foodborne Pathog Dis. 2013 Aug;10(8):744-6. doi: 10.1089/fpd.2012.1468. Epub 2013 Jun 8.
Antimicrobial-resistant bacteria pose a threat to public health. Three Yersinia enterocolitica strains cultured from patients presenting with diarrhea and resistant to nalidixic acid were studied. Target gene mutations in gyrA alone were identified as part of the genetic basis for this phenotype. Efflux activity was also noted, since the presence of the efflux pump inhibitor, phenylalanine-arginine-β-naphthylamide, increased susceptibility to nalidixic acid.
抗微生物药物耐药细菌对公众健康构成威胁。从出现腹泻症状且对萘啶酸耐药的患者中培养出 3 株肠炎沙门氏菌进行了研究。gyrA 基因单独的靶基因突变被确定为这种表型的遗传基础的一部分。还注意到了外排活性，因为外排泵抑制剂苯丙氨酸-精氨酸-β-萘基酰胺的存在增加了对萘啶酸的敏感性。
