对萘啶酸具有不同敏感性的小肠结肠炎耶尔森菌菌株的克隆传播。
Clonal dissemination of Yersinia enterocolitica strains with various susceptibilities to nalidixic acid.
作者信息
Sánchez-Céspedes Javier, Navia Margarita M, Martínez Rocío, Orden Beatriz, Millán Rosario, Ruiz Joaquín, Vila Jordi
机构信息
Servei de Microbiologia, Institut Clínic Infeccions i Immunología, IDIBAPS, Facultat de Medicina, Universitat de Barcelona, 08036 Barcelona, Spain.
出版信息
J Clin Microbiol. 2003 Apr;41(4):1769-71. doi: 10.1128/JCM.41.4.1769-1771.2003.
Abstract
Ten epidemiologically related Yersinia enterocolitica clinical isolates were studied. Six isolates were nalidixic acid resistant (MIC > 512 microg/ml), with mutations in the quinolone resistance-determining region (QRDR) of the gyrA gene, suggesting clonal dissemination of a nalidixic acid-susceptible Y. enterocolitica strain which has acquired different mutations generating resistance to nalidixic acid.
摘要
对10株具有流行病学关联的小肠结肠炎耶尔森菌临床分离株进行了研究。6株分离株对萘啶酸耐药（MIC>512μg/ml），gyrA基因喹诺酮耐药决定区（QRDR）发生突变，提示一株对萘啶酸敏感的小肠结肠炎耶尔森菌菌株发生了克隆传播，该菌株获得了不同的突变从而产生对萘啶酸的耐药性。
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