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[Antimicrobial use in Spanish hospitals (EPINE, 1990-1999)].[西班牙医院的抗菌药物使用情况（EPINE，1990 - 1999年）]
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High prevalence of nalidixic acid resistant, ciprofloxacin susceptible phenotype among clinical isolates of Escherichia coli and other Enterobacteriaceae.大肠杆菌及其他肠杆菌科细菌临床分离株中耐萘啶酸、对环丙沙星敏感表型的高流行率。
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An outbreak of Yersinia enterocolitica O:8 infections associated with pasteurized milk.一起与巴氏杀菌乳相关的小肠结肠炎耶尔森菌O:8感染暴发。
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Efficient subtyping of Yersinia enterocolitica bioserotype 4/O:3 with pulsed-field gel electrophoresis.利用脉冲场凝胶电泳对小肠结肠炎耶尔森菌生物血清型4/O:3进行高效分型
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Analysis of the mechanisms of quinolone resistance in clinical isolates of Citrobacter freundii.弗氏柠檬酸杆菌临床分离株喹诺酮耐药机制分析
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Increase in incidence of resistance to ampicillin, chloramphenicol and trimethoprim in clinical isolates of Salmonella serotype Typhimurium with investigation of molecular epidemiology and mechanisms of resistance.鼠伤寒沙门氏菌临床分离株对氨苄西林、氯霉素和甲氧苄啶耐药性发生率的增加以及分子流行病学和耐药机制的研究
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Genetic heterogeneity of clinical strains of Yersinia enterocolitica traced by ribotyping and relationships between ribotypes, serotypes, and biotypes.通过核糖体分型追踪小肠结肠炎耶尔森菌临床菌株的遗传异质性以及核糖体分型、血清型和生物型之间的关系。
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8
Yersinia enterocolitica serotype O:8 septicemia in an otherwise healthy adult: analysis of chromosome DNA pattern by pulsed-field gel electrophoresis.一名原本健康的成年人发生小肠结肠炎耶尔森菌O:8血清型败血症：采用脉冲场凝胶电泳分析染色体DNA图谱
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Yersinia enterocolitica: the charisma continues.小肠结肠炎耶尔森菌：魅力依旧。
Clin Microbiol Rev. 1997 Apr;10(2):257-76. doi: 10.1128/CMR.10.2.257.
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High frequency of mutations at codon 83 of the gyrA gene of quinolone-resistant clinical isolates of Escherichia coli.喹诺酮耐药性大肠杆菌临床分离株gyrA基因第83位密码子的高频突变
J Antimicrob Chemother. 1995 Oct;36(4):737-8. doi: 10.1093/jac/36.4.737.

对萘啶酸具有不同敏感性的小肠结肠炎耶尔森菌菌株的克隆传播。

Clonal dissemination of Yersinia enterocolitica strains with various susceptibilities to nalidixic acid.

作者信息

Sánchez-Céspedes Javier, Navia Margarita M, Martínez Rocío, Orden Beatriz, Millán Rosario, Ruiz Joaquín, Vila Jordi

机构信息

Servei de Microbiologia, Institut Clínic Infeccions i Immunología, IDIBAPS, Facultat de Medicina, Universitat de Barcelona, 08036 Barcelona, Spain.

出版信息

J Clin Microbiol. 2003 Apr;41(4):1769-71. doi: 10.1128/JCM.41.4.1769-1771.2003.

DOI:10.1128/JCM.41.4.1769-1771.2003
PMID:12682183
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC153901/
Abstract

Ten epidemiologically related Yersinia enterocolitica clinical isolates were studied. Six isolates were nalidixic acid resistant (MIC > 512 microg/ml), with mutations in the quinolone resistance-determining region (QRDR) of the gyrA gene, suggesting clonal dissemination of a nalidixic acid-susceptible Y. enterocolitica strain which has acquired different mutations generating resistance to nalidixic acid.

摘要

对10株具有流行病学关联的小肠结肠炎耶尔森菌临床分离株进行了研究。6株分离株对萘啶酸耐药（MIC>512μg/ml），gyrA基因喹诺酮耐药决定区（QRDR）发生突变，提示一株对萘啶酸敏感的小肠结肠炎耶尔森菌菌株发生了克隆传播，该菌株获得了不同的突变从而产生对萘啶酸的耐药性。