Gruber-Dujardin E, Jurczynski K, Kaup F-J, Mätz-Rensing K
Pathology Unit, German Primate Center, Göttingen, Germany.
J Comp Pathol. 2013 Nov;149(4):509-13. doi: 10.1016/j.jcpa.2013.04.002. Epub 2013 Jun 6.
Oncocytic adrenocortical tumours are rare in man and have never been described in non-human primates. An oncocytic adrenocortical carcinoma was identified in an 18-year-old female putty-nosed monkey (Cercopithecus nictitans) with hyperadrenocorticism and invasive aspergillosis. Microscopically, the tumour consisted of large cells with abundant eosinophilic, granular cytoplasm containing numerous mitochondria as identified by electron microscopy. Tumour cells had large nuclei with occasional intranuclear cytoplasmic pseudoinclusions. Immunohistochemically, tumour cells expressed vimentin, synaptophysin and neuron-specific enolase, while they were negative for cytokeratin, chromogranin-A, melan-A and S100.
嗜酸性肾上腺皮质肿瘤在人类中较为罕见，在非人类灵长类动物中尚未见报道。在一只患有肾上腺皮质功能亢进和侵袭性曲霉菌病的18岁雌性白鼻猴（白睑猴）中发现了一例嗜酸性肾上腺皮质癌。显微镜下，肿瘤由大细胞组成，这些细胞具有丰富的嗜酸性颗粒状细胞质，电子显微镜鉴定显示其中含有大量线粒体。肿瘤细胞有大细胞核，偶尔可见核内胞质假包涵体。免疫组织化学检查显示，肿瘤细胞表达波形蛋白、突触素和神经元特异性烯醇化酶，而细胞角蛋白、嗜铬粒蛋白A、黑色素A和S100均为阴性。
