Krishnamurthy S, Ordóñez N G, Shelton T O, Ayala A G, Sneige N
Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.
Diagn Cytopathol. 2000 May;22(5):299-303. doi: 10.1002/(sici)1097-0339(200005)22:5<299::aid-dc8>3.0.co;2-5.
We report on the results of fine-needle aspiration cytology of a case of oncocytic adrenocortical carcinoma in a 39-yr-old man. The tumor invaded the inferior vena cava and extended up to the right atrium. Aspirate smears were very cellular and showed a monomorphic population of large polyhedral cells with abundant granular cytoplasm, predominantly distributed singly. Mitotic activity was inconspicuous, and there was no necrosis. Immunohistochemically, the tumor cells were positive for vimentin, cytokeratin, and p53, and negative for synaptophysin, chromogranin, inhibin, and S-100. Ultrastructurally, the cytoplasm of the tumor cells was packed with mitochondria. The patient underwent left radical nephrectomy as well as a combined cardiopulmonary bypass, with atriotomy and resection of the tumor from the right atrium and inferior vena cava. Three months of postoperative follow-up were uneventful.
我们报告了一名39岁男性嗜酸细胞性肾上腺皮质癌患者的细针穿刺细胞学检查结果。肿瘤侵犯下腔静脉并延伸至右心房。穿刺涂片细胞丰富，可见大量单一形态的大的多面体细胞，细胞质丰富且呈颗粒状，主要单个分布。有丝分裂活动不明显，未见坏死。免疫组化显示，肿瘤细胞波形蛋白、细胞角蛋白和p53呈阳性，突触素、嗜铬粒蛋白、抑制素和S-100呈阴性。超微结构显示，肿瘤细胞的细胞质中充满线粒体。患者接受了左肾根治性切除术以及体外循环联合手术，通过心房切开术从右心房和下腔静脉切除肿瘤。术后三个月随访无异常。
