Russo Finizia, Maruccio Lucianna, Calamo Antonio, de Girolamo Paolo, Varricchio Ettore
Department of Biological, Geological and Environmental Sciences, University of Sannio, Via Port'Arsa 11, 82100 Benevento, Italy.
Department of Veterinary Medicine and Animal Productions, University of "Federico II", Via Veterinaria 1, 80137 Napoli, Italy.
Acta Histochem. 2014 Jan;116(1):286-8. doi: 10.1016/j.acthis.2013.04.012. Epub 2013 Jun 6.
Orexin receptor 1 (OX₁R) and orexin receptor 2 (OX₂R) are two G-protein-coupled receptors that bind their ligands, orexin A (OXA) and B (OXB), with different affinities. The male genital system represents an important target for OXA, which appears to play a role in the control of steroidogenesis and germ cell development in the testis. It is known that among domestic breeding animals, in the boar the number of Leydig cells is very high and OXA appears to have stimulatory activity on testosterone production. In this study, we aimed to evaluate the presence of OX₁R in the boar testis in order to extend our knowledge concerning the distribution and a potential functional role of the orexinergic system in the male reproductive tract of farm animals. The presence of OX₁R immunopositive cells in seminiferous tubules of the boar testis enables us to hypothesize a possible role of OXA on male germ cells cycle in pig. Further investigations, involving functional and ultrastructural analysis, may contribute to our understanding of the role of orexins in the boar genital system.
食欲素受体1（OX₁R）和食欲素受体2（OX₂R）是两种G蛋白偶联受体，它们以不同亲和力结合其配体食欲素A（OXA）和B（OXB）。雄性生殖系统是OXA的一个重要靶标，OXA似乎在睾丸类固醇生成和生殖细胞发育的调控中发挥作用。众所周知，在驯养动物中，公猪的睾丸间质细胞数量非常多，且OXA似乎对睾酮生成具有刺激活性。在本研究中，我们旨在评估公猪睾丸中OX₁R的存在情况，以拓展我们对食欲素能系统在农场动物雄性生殖道中的分布及潜在功能作用的认识。公猪睾丸生精小管中存在OX₁R免疫阳性细胞，这使我们能够推测OXA在猪雄性生殖细胞周期中可能发挥的作用。进一步涉及功能和超微结构分析的研究可能有助于我们理解食欲素在公猪生殖系统中的作用。
