Department of Veterinary Medicine, Perugia, Italy.
Department of Veterinary Medicine, Perugia, Italy.
Acta Histochem. 2014 Jun;116(5):989-92. doi: 10.1016/j.acthis.2014.03.004. Epub 2014 Apr 16.
The aim of the present study was to examine the presence and distribution of cells that express immunopositivity for orexin A (OXA) and its type 2 receptor (OX2R) in the dog placenta toward the end of pregnancy using immunohistochemical techniques. In the placental fetal portion, a few OXA and OX2R-positive cells were seen scattered in the outermost coating layer of chorionic villi and in the trophoblastic protrusions. Closer to the maternal portion, immunopositive labeling for both peptides was visible in the glandular epithelia and that for OXA also in the endothelium of the capillaries. These observations allow us to hypothesize that the canine placenta may be not only a source of orexin A, but also its target, and that orexin A may play an important role in controlling the function of this important organ for normal fetal development.
本研究旨在使用免疫组织化学技术检测怀孕末期犬胎盘内表达食欲素 A（OXA）及其 2 型受体（OX2R）免疫阳性的细胞的存在和分布。在胎盘胎儿部分，可见少数 OXA 和 OX2R 阳性细胞散在绒毛膜绒毛的最外层和滋养细胞突起中。靠近母体部分，两种肽的免疫阳性标记均可见于腺上皮，而 OXA 的免疫阳性标记也可见于毛细血管内皮。这些观察结果使我们假设犬胎盘不仅可能是食欲素 A 的来源，而且可能是其靶标，并且食欲素 A 可能在控制这个对正常胎儿发育至关重要的器官的功能方面发挥重要作用。
