AKT1 基因变异与精神分裂症无关：一项马来西亚病例对照研究和荟萃分析。
No association between AKT1 gene variants and schizophrenia: a Malaysian case-control study and meta-analysis.
机构信息
Department of Chemical Engineering, Faculty of Engineering and Science (FES), Universiti Tunku Abdul Rahman (UTAR), Jalan Genting Kelang, Setapak, 53300 Kuala Lumpur, Malaysia; High Impact Research Office, Level 9, Chancellery Building, University of Malaya (UM), 50603 Kuala Lumpur, Malaysia.
出版信息
Psychiatry Res. 2013 Oct 30;209(3):732-3. doi: 10.1016/j.psychres.2013.05.017. Epub 2013 Jun 5.
We aim to replicate AKT1 gene variants studies using Malaysian samples. Seven AKT1 single nucleotide polymorphisms (SNPs) were studied in 417 patients and 429 controls. Haplotype showed significant association (p=0.036) with schizophrenia, especially in Malays and Indians. Meta-analysis of rs2494732 showed significant association worldwide (p=0.018) and in Asians (p=0.023).
我们旨在使用马来西亚样本复制 AKT1 基因变异研究。在 417 名患者和 429 名对照中研究了 7 个 AKT1 单核苷酸多态性 (SNP)。单体型与精神分裂症显著相关 (p=0.036)，尤其是在马来人和印度人中。rs2494732 的荟萃分析显示在全球范围内 (p=0.018) 和亚洲人群中 (p=0.023) 存在显著相关性。
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