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2-肉桂酰胺基、2-(3-苯丙炔酰胺基)和 2-(3-苯丙酰胺基)苯甲酰胺的合成、抗增殖活性及作用机制。

2-cinnamamido, 2-(3-phenylpropiolamido), and 2-(3-phenylpropanamido)benzamides: synthesis, antiproliferative activity, and mechanism of action.

机构信息

Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche, Via Archirafi, 32, 90123 Palermo, Italy.

出版信息

Eur J Med Chem. 2013 Jul;65:427-35. doi: 10.1016/j.ejmech.2013.04.068. Epub 2013 May 14.

DOI:10.1016/j.ejmech.2013.04.068
PMID:23747810
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3731050/
Abstract

Several new benzamides 4a-q were synthesized by stirring in pyridine the acid chlorides 3a-q with the appropriate anthranilamide derivatives 2a-g. Some of the synthesized compounds were evaluated for their in vitro antiproliferative activity against a panel of 5 human cell lines (K562 human chronic myelogenous leukemia cells, MCF-7 breast cancer cells, HTC-116 and HT26 colon cancer cells and NCI H460 non-small cell lung cancer cells).

摘要

几种新的苯甲酰胺 4a-q 通过在吡啶中搅拌酰氯 3a-q 与合适的邻氨基苯甲酰胺衍生物 2a-g 合成。一些合成的化合物被评估了它们对 5 个人类细胞系（K562 人慢性髓系白血病细胞、MCF-7 乳腺癌细胞、HTC-116 和 HT26 结肠癌细胞和 NCI H460 非小细胞肺癌细胞）的体外增殖活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e89/3731050/a3f0e0fbe8fd/nihms490246f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e89/3731050/56f214f1fbfd/nihms490246f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e89/3731050/f61bd2d729b3/nihms490246f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e89/3731050/3ab97c4b8b4e/nihms490246f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e89/3731050/a3f0e0fbe8fd/nihms490246f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e89/3731050/56f214f1fbfd/nihms490246f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e89/3731050/f61bd2d729b3/nihms490246f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e89/3731050/3ab97c4b8b4e/nihms490246f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e89/3731050/a3f0e0fbe8fd/nihms490246f4.jpg

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