Department of Radiolog, Shanghai Ninth Peoples Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Front Biosci (Landmark Ed). 2013 Jun 1;18(3):1098-111. doi: 10.2741/4166.
The combination of dynamic contrast-enhanced (DCE) and diffusion-weighted (DW)-MRI adds important information to the findings obtained through conventional spin echo MRI. We aimed to determine the value of combined DW- and DCE-MRI in distinguishing benign from malignant tumors of the tongue and mouth floor. The apparent diffusion coefficient (ADC) maps were constructed, and the ADC values of the lesions were calculated from DW-MRI. The slopes were derived from time-intensity curves (TICs) from DCE-MRI. The ADC map for malignant tumors was lower compared with the benign lesions. The slope in the malignant tumors was significantly greater compared with the benign lesions. In malignant tumors, the ADC(b=500) threshold of <1.43 10(-3) mm2/s yielded a sensitivity, specificity, and accuracy of 74.6%, 83.3%, and 79.7%, respectively. For benign lesions, a slope threshold of <38.6 yielded a sensitivity, specificity, and accuracy of 80.3%, 74.5%, and 77.9%, respectively. Combined DCE- and DW-MR imaging may provide valuable information that allows for the differentiation between benign lesions and malignant tumors of the tongue and mouth floor.
动态对比增强（DCE）和弥散加权（DW）MRI 的结合为常规自旋回波 MRI 获得的发现提供了重要信息。我们旨在确定 DW 和 DCE-MRI 联合在区分舌和口腔底部的良性和恶性肿瘤方面的价值。构建了表观弥散系数（ADC）图，并从 DW-MRI 计算了病变的 ADC 值。从 DCE-MRI 的时间强度曲线（TIC）中得出斜率。与良性病变相比，恶性肿瘤的 ADC 图较低。恶性肿瘤的斜率明显大于良性病变。在恶性肿瘤中，ADC（b=500）<1.43 10(-3) mm2/s 的阈值的敏感性、特异性和准确性分别为 74.6%、83.3%和 79.7%。对于良性病变，斜率阈值<38.6 的敏感性、特异性和准确性分别为 80.3%、74.5%和 77.9%。DCE 和 DW-MRI 联合成像可能提供有价值的信息，有助于区分舌和口腔底部的良性和恶性肿瘤。
