Department of Anesthetics, Shanghai Ninth People's Hospital affiliated with Shanghai Jiao Tong University, School of Medicine, Shanghai 200011, China.
Front Biosci (Landmark Ed). 2013 Jun 1;18(4):1244-55. doi: 10.2741/4176.
Indirect acute lung injury (IALI) manifests as rapid-onset respiratory failure following secondary clinical events to the parenchyma or lung vasculature, such as hemorrhage shock, extra-pulmonary sepsis, trauma, ischemia-reperfusion, and burn injury. Accumulating evidence demonstrates the pivotal role of pattern recognition receptors (PRRs) in the innate immune system of lung diseases. Toll like receptor 4 (TLR4), one of the well characterized PRRs, recognizes not only the lipopolysaccharide (LPS) of Gram-negative bacteria, but also the endogenous ligands in IALI. In this review, we summarize a variety of reports concerning the role of TLR4 and IALI pathogenesis.
间接性急性肺损伤（IALI）继发于实质或肺血管的临床事件后，表现为呼吸衰竭迅速发生，例如出血性休克、肺外脓毒症、创伤、缺血再灌注和烧伤损伤。越来越多的证据表明，模式识别受体（PRRs）在肺部疾病的固有免疫系统中起着关键作用。Toll 样受体 4（TLR4）是一种特征明确的 PRRs 之一，它不仅识别革兰氏阴性菌的脂多糖（LPS），还识别 IALI 中的内源性配体。在这篇综述中，我们总结了多种关于 TLR4 和 IALI 发病机制的报告。
