Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Rome, Italy.
Front Biosci (Landmark Ed). 2013 Jun 1;18(4):1290-310. doi: 10.2741/4180.
Carcinogenesis is a multi-step process triggered by cumulative genetic alterations, which drive the progressive transformation of a normal cell into a cancer cell. Among the signal transduction pathways whose cross-talk plays an important role in neoplastic transformation are those mediated by ErbB receptors, NF-kappaB and the Hedgehog (HH)/glioma-associated oncogene (GLI) cascade. Polyphenols can be employed to inhibit the growth of cancer cells due to their ability to modulate the activity of multiple targets involved in carcinogenesis through simultaneous direct interaction or modulation of gene expression. This review will describe the cross-talk between ErbB receptors, NF-kappaB and the Hedgehog (HH)/glioma-associated oncogene (GLI) signaling pathways and the potential role of polyphenols in inhibiting this dialogue and the growth of cancer cells.
致癌作用是一个多步骤的过程，由累积的遗传改变引发，推动正常细胞逐渐转化为癌细胞。在那些信号转导通路中，其相互作用在肿瘤转化中起着重要作用，包括由 ErbB 受体、NF-κB 和 Hedgehog（HH）/神经胶质瘤相关癌基因（GLI）级联介导的信号通路。多酚可以通过同时直接相互作用或调节参与致癌作用的多个靶标来调节基因表达，从而抑制癌细胞的生长。本综述将描述 ErbB 受体、NF-κB 和 Hedgehog（HH）/神经胶质瘤相关癌基因（GLI）信号通路之间的相互作用，以及多酚在抑制这种对话和癌细胞生长中的潜在作用。
