中国人群中CYP11B2 -344T/C基因多态性与短暂性脑缺血发作之间不存在关联。
Lack of association between CYP11B2 -344T/C polymorphism and transient ischemic attack in a Chinese population.
作者信息
Fan Jia, Shen Yaoliang, Chen Bo, Xu Chunyang, Ye Hongwei, Wang Jian, Zhou Wenjun, Sheng Yuefeng, Xu Feng, Yang Peng
机构信息
Changshu First People's Hospital Affiliated to Soochow University, Changshu, Jiangsu, China.
The Fifth People's Hospital of Changshu, Changshu, Jiangsu, China.
出版信息
J Int Med Res. 2020 Aug;48(8):300060520947916. doi: 10.1177/0300060520947916.
OBJECTIVE
This study investigated whether the CYP11B2 -344T/C polymorphism is correlated with transient ischemic attack (TIA) susceptibility.
METHODS
We recruited 100 TIA patients and 100 control subjects and analyzed the CYP11B2 -344T/C polymorphism using restriction fragment length polymorphism (PCR-RFLP).
RESULTS
The frequency in TIA patients and controls was 42% compared with 48% for TT genotypes, 51% compared with 45% for TC genotypes, and 7% compared with 7% for CC genotype, respectively. Allele frequencies in TIA patients and controls were 67.5% compared with 70.5% for T-allele and 32.5% compared with 29.5% for C-allele, respectively. No association between the CYP11B2 -344T/C polymorphism and TIA was observed in all comparisons.
CONCLUSION
Our data suggest that there was no association between the CYP11B2 -344T/C polymorphism and TIA in a Chinese population.
目的
本研究调查CYP11B2 -344T/C基因多态性是否与短暂性脑缺血发作（TIA）易感性相关。
方法
我们招募了100例TIA患者和100例对照者，采用限制性片段长度多态性方法（PCR-RFLP）分析CYP11B2 -344T/C基因多态性。
结果
TIA患者和对照者中，TT基因型频率分别为42%和48%，TC基因型频率分别为51%和45%，CC基因型频率分别为7%和7%。TIA患者和对照者的等位基因频率中，T等位基因分别为67.5%和70.5%，C等位基因分别为32.5%和29.5%。所有比较中均未观察到CYP11B2 -344T/C基因多态性与TIA之间存在关联。
结论
我们的数据表明，在中国人群中，CYP11B2 -344T/C基因多态性与TIA之间不存在关联。
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