Senèze J
Rev Fr Gynecol Obstet. 1990 May;85(5):301-5.
In the long history of oral contraception, unfortunate events have been associated with the use of oestrogens and progestogens. The discovery of new progestational hormones with weak androgenic activity but powerful progestational action has led to the combination of very low doses of ethinyloestradiol with low doses of progestational hormones which progressively increase in three successive stages. The products thus show excellent safety, accompanied by a minimum of incidents, and are extremely reliable contraceptives.
在口服避孕药的漫长历史中，使用雌激素和孕激素曾引发过不幸事件。具有弱雄激素活性但强大孕激素作用的新型孕激素的发现，促使极低剂量的炔雌醇与低剂量孕激素相结合，且孕激素剂量在三个连续阶段逐渐增加。由此产生的产品安全性极佳，副作用最少，是极为可靠的避孕药。
