Manzella Nicola, Bracci Massimo, Staffolani Sara, Strafella Elisabetta, Rapisarda Venerando, Valentino Matteo, Amati Monica, Copertaro Alfredo, Santarelli Lory
Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy.
Biosci Biotechnol Biochem. 2013;77(6):1296-8. doi: 10.1271/bbb.120944. Epub 2013 Jun 7.
The circadian clock can regulate the metabolic process of xenobiotics, but little is known as to circadian rhythms can be perturbed by xenobiotics. Styrene is a organic chemical widely used in occupational settings. The effects of styrene on the circadian genes of HuDE cells were evaluated after serum-shocking synchronization. A subtoxic dose of 100 µM of styrene altered the expression of clock genes BMAL1, PER2, PER3, CRY1, CRY2, and REV-ERB-α.
昼夜节律时钟可以调节外源性物质的代谢过程，但关于外源性物质是否会扰乱昼夜节律却知之甚少。苯乙烯是一种在职业环境中广泛使用的有机化学品。血清休克同步化后，评估了苯乙烯对人真皮成纤维细胞（HuDE细胞）昼夜节律基因的影响。100μM的亚毒性剂量苯乙烯改变了生物钟基因BMAL1、PER2、PER3、CRY1、CRY2和REV-ERB-α的表达。
