Department of Pathology, Catholic University of the Sacred Heart, Rome, Italy.
Virchows Arch. 2013 Jul;463(1):23-9. doi: 10.1007/s00428-013-1436-y. Epub 2013 Jun 10.
The occurrence of a secondary malignancy in the uterine cervix is a very rare event. In the vast majority of cases, this secondary involvement concerns direct spread of a uterine malignancy to the cervix. However, cancer of the ovary, breast, stomach, gallbladder, pancreas and lung has been reported to metastasize to the uterine cervix by hematogenous route. In this context, secondary lesions of the uterine cervix, in particular those of non-epithelial and extra-genital origin, are sufficiently rare to be overlooked, which might result in inappropriate diagnosis with disappointing consequences in terms of treatment planning. We report a single-institution consecutive series of 144 cases of secondary malignancy of the uterine cervix, emphasizing the morphological and immunohistochemical criteria required to arrive at a correct final diagnosis. Secondary malignancies of the uterine cervix have a protean appearance and can present with a wide spectrum of symptoms. Almost invariably metastases to the cervix signal devastating spread to many different organs. Histopathology, as well as immunohistochemical features and close collaboration between clinicians and pathologists, is essential to arrive at a correct final diagnosis.
宫颈继发恶性肿瘤的发生非常罕见。在绝大多数情况下，这种继发累及涉及子宫恶性肿瘤直接向宫颈扩散。然而，卵巢癌、乳腺癌、胃癌、胆囊癌、胰腺癌和肺癌已被报道通过血行途径转移至宫颈。在这种情况下，宫颈的继发性病变，特别是非上皮性和外生殖器来源的病变，非常罕见，容易被忽视，这可能导致不适当的诊断，从而对治疗计划产生令人失望的后果。我们报告了 144 例宫颈继发性恶性肿瘤的单机构连续病例系列，强调了为得出正确最终诊断所需的形态学和免疫组织化学标准。宫颈继发性恶性肿瘤表现多样，可能出现广泛的症状。几乎无一例外地，宫颈转移提示广泛播散至许多不同的器官。组织病理学，以及免疫组织化学特征和临床医生与病理学家之间的密切合作，对于得出正确的最终诊断至关重要。
