Liu Huiming, Wang Qifeng, Jia Xitang, Liu Bo, Wang C-K Chris
Department of Radiation Oncology, District Hospital of Changzhi city, Shanxi, PRC.
Tumori. 2013 Mar-Apr;99(2):172-5. doi: 10.1177/030089161309900209.
Californium-252 (²⁵²Cf) neutron brachytherapy is a form of high linear energy transfer radiotherapy, which has proven effective when used in combination with external beam radiotherapy to treat intracavitary cancers of the cervix, colon/rectum and esophagus. No study has been reported for treatment of intracavitary cancers with neutron brachytherapy alone. The aim of the study was to observe and analyze the long-term curative effects and complications for early stage thoracic esophageal cancer patients treated with neutron brachytherapy alone.
From December 2001 to August 2006, 16 patients of early stage squamous cell carcinoma underwent neutron brachytherapy. The total radiation dose to the reference point was 20-28 Gy-eq in 5 to 7 fractions with 4 Gy-eq/fraction. The 1-, 3-, and 5-year follow-up rates were 100%.
The 2-, 3-, 4-, and 5-year survival rates were 100%, 87.5%, 87.5%, and 75%, respectively. The early complication rates for grades 1 and 2 radiation esophagitis were 75% and 25%, respectively. The late complication rates for grades 0 and 1 (according to the RTOG/EORTC standard) were 87.5% and 12.5%, respectively. Barium esophagography after treatments confirmed that the complete response rate was 100%. Fourteen patients were confirmed by endoscopy to have either normal mucosa or inflammation change.
Neutron brachytherapy alone was an effective and safe treatment for early stage esophageal squamous cell cancer.
锎 - 252（²⁵²Cf）中子近距离放射治疗是一种高传能线密度放射治疗形式，已证实与外照射放疗联合用于治疗子宫颈、结肠/直肠和食管腔内癌时有效。尚无单独使用中子近距离放射治疗腔内癌的研究报道。本研究的目的是观察和分析单纯中子近距离放射治疗早期胸段食管癌患者的长期疗效和并发症。
2001年12月至2006年8月，16例早期鳞状细胞癌患者接受了中子近距离放射治疗。参考点的总辐射剂量为20 - 28 Gy - eq，分5至7次给予，每次4 Gy - eq。1年、3年和5年的随访率均为100%。
2年、3年、4年和5年生存率分别为100%、87.5%、87.5%和75%。1级和2级放射性食管炎的早期并发症发生率分别为75%和25%。0级和1级（根据RTOG/EORTC标准）的晚期并发症发生率分别为87.5%和12.5%。治疗后的食管钡餐造影证实完全缓解率为100%。14例患者经内镜检查证实黏膜正常或有炎症改变。
单纯中子近距离放射治疗是早期食管鳞状细胞癌的一种有效且安全的治疗方法。
