Wang Qifeng, Li Tao, Lang Jinyi, Wang Jie, Wang Jian, Liu Huiming, Jia Xitang, Liu Bo, Wang C-K Chris
Department of Radiation Oncology, Sichuan Cancer Hospital, Chengdu, Sichuan, 610041, P.R. China.
Department of Radiation Oncology, Changzhi Cancer Hospital, Changzhi, Shanxi, 046000, P.R. China.
Radiat Oncol. 2015 Oct 24;10:212. doi: 10.1186/s13014-015-0520-7.
We conducted a retrospective analysis on 884 patients who were diagnosed with esophageal squamous cell carcinoma (ESCC) and treated with either the neutron brachytherapy in combination with external beam radiotherapy (NBT + EBRT) or 3-dimensional conformal radiation therapy (3D-CRT) to determine the differences in efficacy and morbidity between the two treatment groups.
The 884 ESCC patients treated with either NBT + EBRT or 3D-CRT between 2002 and 2012 were retrospectively reviewed and analyzed. Multivariable Cox regression was used to compare oncologic outcomes of the two groups of patients in the context of other clinically relevant variables. The acute and chronic toxicities associated with the two groups were compared using Fisher exact and log-rank tests, respectively.
Among the 884 patients, 545 received NBT + EBRT and 339 received 3D-CRT (i.e. EBRT-only). The age range is 39-95 years (median 66). The follow-up time range is 3-145 months (median 32). The analysis shows that the NBT + EBRT group has higher overall survival rate and local control rate than that of the 3D-CRT group. The acute toxicity effects were acceptable for both groups of patients with the NBT + EBRT group showing higher rates of leukopenia and thrombocytopenia and the 3D-CRT group showing higher rates on fistula and massive bleeding.
The patients treated with NBT + EBRT showed better oncologic outcomes than those treated with 3D-CRT. The toxicity effects were acceptable for both groups with the NBT + EBRT group showing higher rates on the acute effects and the 3D-CRT group showing higher rates on the late effects.
我们对884例被诊断为食管鳞状细胞癌（ESCC）并接受中子近距离放疗联合外照射放疗（NBT + EBRT）或三维适形放疗（3D - CRT）的患者进行了回顾性分析，以确定两个治疗组在疗效和发病率方面的差异。
回顾性分析2002年至2012年间接受NBT + EBRT或3D - CRT治疗的884例ESCC患者。多变量Cox回归用于在其他临床相关变量的背景下比较两组患者的肿瘤学结局。分别使用Fisher精确检验和对数秩检验比较两组相关的急性和慢性毒性。
在884例患者中，545例接受NBT + EBRT，339例接受3D - CRT（即单纯EBRT）。年龄范围为39 - 95岁（中位数66岁）。随访时间范围为3 - 145个月（中位数32个月）。分析表明，NBT + EBRT组的总生存率和局部控制率高于3D - CRT组。两组患者的急性毒性反应均可接受，NBT + EBRT组白细胞减少和血小板减少发生率较高，3D - CRT组瘘管和大出血发生率较高。
接受NBT + EBRT治疗的患者比接受3D - CRT治疗的患者显示出更好的肿瘤学结局。两组的毒性反应均可接受，NBT + EBRT组急性反应发生率较高，3D - CRT组晚期反应发生率较高。
