School of Computer and Communication Sciences and School of Life Science, Brain Mind Institute, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Nat Neurosci. 2013 Jul;16(7):942-8. doi: 10.1038/nn.3431. Epub 2013 Jun 9.
Spike-frequency adaptation (SFA) is widespread in the CNS, but its function remains unclear. In neocortical pyramidal neurons, adaptation manifests itself by an increase in the firing threshold and by adaptation currents triggered after each spike. Combining electrophysiological recordings in mice with modeling, we found that these adaptation processes lasted for more than 20 s and decayed over multiple timescales according to a power law. The power-law decay associated with adaptation mirrored and canceled the temporal correlations of input current received in vivo at the somata of layer 2/3 somatosensory pyramidal neurons. These findings suggest that, in the cortex, SFA causes temporal decorrelation of output spikes (temporal whitening), an energy-efficient coding procedure that, at high signal-to-noise ratio, improves the information transfer.
棘波频率适应（SFA）在中枢神经系统中广泛存在，但它的功能仍不清楚。在新皮层锥体神经元中，适应表现为发射阈值的增加和每个棘波后触发的适应电流。我们结合小鼠的电生理记录和建模发现，这些适应过程持续超过 20 秒，并根据幂律衰减跨越多个时间尺度。与适应相关的幂律衰减反映并消除了体内层 2/3 体感锥体神经元树突体接收的输入电流的时间相关性。这些发现表明，在皮层中，SFA 导致输出尖峰的时间去相关（时间白化），这是一种节能的编码过程，在高信噪比下，提高了信息传递。
