Kamal Saurabh, Yadava Usha, Kumar Sushil, Goel Ruchi
Guru Nanak Eye Centre, Maulana Azad Medical College, New Delhi, 110002, India,
Int Ophthalmol. 2014 Apr;34(2):345-9. doi: 10.1007/s10792-013-9793-8. Epub 2013 Jun 8.
Topiramate is a recognized cause of drug-induced acute angle-closure glaucoma. We describe a case presenting with bilateral acute angle-closure glaucoma caused by topiramate intake. Patient subsequently developed severe anterior uveitis caused by sulphonamide derivatives (acetazolamide and co-trimoxazole) due to cross-sensitivity, on two separate occasions. The present case also highlights the role of anterior segment optical tomography in diagnosis and follow-up. In a patient with known drug allergy to topiramate, other sulphonamide derivatives should be avoided to limit the ocular morbidity.
托吡酯是药物性急性闭角型青光眼的一个公认病因。我们描述了一例因服用托吡酯导致双侧急性闭角型青光眼的病例。该患者随后因交叉敏感性，在两个不同的场合分别出现了由磺胺类衍生物（乙酰唑胺和复方新诺明）引起的严重前葡萄膜炎。本病例还强调了眼前节光学相干断层扫描在诊断和随访中的作用。对于已知对托吡酯过敏的患者，应避免使用其他磺胺类衍生物，以减少眼部发病率。
