Feng J Q, Chen P X
Department of Physiology, Sun Yat Sen University of Medical Sciences, Guangzhou.
Sheng Li Xue Bao. 1990 Apr;42(2):129-34.
The effect of stimulation of cerebral anterior lateral association area (ALA) on evoked potentials recorded in the primary somatosensory cortex (SI), elicited by C-fiber inputs of saphenous nerve (C-CEP) was investigated in cats anesthetized with chloralose and immobilized by Flaxedil. Following 1 min electric stimulation of ALA (0.1 mA, 100 Hz, duration 0.2 ms), the amplitudes of C-CEP were obviously decreased, indicating that ALA had an inhibitory effect on C-CEP. In order to explore the neural pathway underlying the inhibition of C-CEP by ALA stimulation, a vertical section between ALA and SI was made. It was shown that the inhibition of C-CEP produced by ALA stimulation was reduced considerably and the time course of the inhibition was shortened after the section. Moreover, the ALA stimulation-produced inhibition was also blocked partially 7 min after the intraventricular injection of naloxone (25 micrograms/50 microliters). The results suggest that ALA may exert an inhibitory effect on C-CEP, which is mediated by endogenous opiate like substances and through the nervous connection between ALA and SI. The cerebral association area may play a role in the modulation of C-CEP.
在用氯醛糖麻醉并用三碘季铵酚麻痹的猫身上，研究了刺激大脑前外侧联合区（ALA）对隐神经C纤维传入（C-CEP）在初级体感皮层（SI）记录的诱发电位的影响。在对ALA进行1分钟的电刺激（0.1 mA，100 Hz，持续时间0.2 ms）后，C-CEP的振幅明显降低，表明ALA对C-CEP有抑制作用。为了探究ALA刺激抑制C-CEP的神经通路，在ALA和SI之间做了一个垂直切片。结果显示，切片后ALA刺激产生的对C-CEP的抑制作用明显减弱，且抑制的时间进程缩短。此外，脑室内注射纳洛酮（25微克/50微升）7分钟后，ALA刺激产生的抑制作用也被部分阻断。结果表明，ALA可能对C-CEP发挥抑制作用，这是由内源性阿片样物质介导，并通过ALA和SI之间的神经连接实现的。大脑联合区可能在C-CEP的调制中发挥作用。
