Zhang J M, Guo L N, Chen P X
Zhen Ci Yan Jiu. 1989;14(4):410-3.
In this paper the averaged cortical evoked potential (C-CEP) induced by stimulating the C-fibers of the splanchnic nerve was used as an index of visceral pain to further study the effects of acupuncture and morphine on it. Experiments were carried out on 35 cats anesthetized with chloralose and immobilized with flaxedil. The splanchnic nerve was stimulated with electric pulses of varied strength and blocked by a galvanic current so as to cause A- or C-fibers input selectively. The cortical evoked potential was recorded on the contralateral post-sigmoid gyrus and averaged by TQ-19 Medical Data Processor. The compound action potential of splanchnic nerve was monitored. "Neiguan" acupoint was stimulated with electric pulses (0.1ms, 4v and 5Hz). The results were as follows: 1) when "Neiguan" acupoint, was excited with the electric pulses, C-CEP and the late component of A-CEP which was evoked by stimulating A-fibers of splanchnic nerve were obviously reduced in amplitudes. It was suggested that electro-acupuncture (EA) of "Neiguan" acupoint could inhibit visceral pain (the slow and fast pain). 2. After intravenous injection of morphine, the amplitudes of C-CEP and the late component of A-CEP were depressed significantly, indicating that C-CEP might reflect the visceral slow pain and the late component of A-CEP reflect the fast pain. 3. Naloxone could block partially the inhibitory effect of EA of "Neiguan" acupoint on C-CEP, suggesting that the inhibition of EA might be associated with the release of endogenous opiate like substances.
本文采用刺激内脏神经C纤维诱发的平均皮层诱发电位（C-CEP）作为内脏痛指标，进一步研究针刺和吗啡对其的影响。实验在35只用氯醛糖麻醉并用三碘季铵酚制动的猫身上进行。用不同强度的电脉冲刺激内脏神经，并用直流电阻断，以选择性地引起A纤维或C纤维传入。在对侧乙状结肠后回记录皮层诱发电位，并用TQ-19医学数据处理仪进行平均。监测内脏神经的复合动作电位。用电脉冲（0.1ms，4v，5Hz）刺激“内关”穴。结果如下：1）当用“内关”穴电刺激时，C-CEP和刺激内脏神经A纤维诱发的A-CEP晚期成分的波幅明显降低。提示针刺“内关”穴可抑制内脏痛（慢痛和快痛）。2.静脉注射吗啡后，C-CEP和A-CEP晚期成分的波幅明显降低，表明C-CEP可能反映内脏慢痛，A-CEP晚期成分反映快痛。3.纳洛酮可部分阻断针刺“内关”穴对C-CEP的抑制作用，提示针刺的抑制作用可能与内源性阿片样物质的释放有关。
