Department of Developmental and Regenerative Dentistry, School of Life Dentistry at Tokyo, The Nippon Dental University, 1-9-20 Fujimi, Chiyoda-ku, Tokyo, 102-8159, Japan.
Anat Rec (Hoboken). 2013 Aug;296(8):1247-54. doi: 10.1002/ar.22725. Epub 2013 Jun 8.
The miniature pig is a useful large laboratory animal model. Various tissues and organs of miniature pigs are similar to those of humans in terms of developmental, anatomical, immunological, and physiological characteristics. The oral and maxillofacial region of miniature pigs is often used in preclinical studies of regenerative dentistry. However, there is limited information on the dentition and tooth structure of miniature pigs. The purpose of this study was to examine the time-course changes of dentition and tooth structure (especially the root) of the miniature pig mandibular cheek teeth through X-ray analyses using soft X-ray for two-dimensional observations and micro-CT for three-dimensional observations. The mandibles of male Clawn strain miniature pigs (2 weeks and 3, 5, 7, 9, 11, 14, 17, and 29 months of age) were used. X-ray analysis of the dentition of miniature pig cheek teeth showed that the eruption pattern of the miniature pig is diphyodont and that the replacement pattern is vertical. Previous definitions of deciduous and permanent teeth often varied and there has been no consensus on the number of teeth (dentition); however, we found that three molars are present in the deciduous dentition and that four premolars and three molars are present in the permanent dentition. Furthermore, we confirmed the number of tooth roots and root canals. We believe that these findings will be highly useful in future studies using miniature pig teeth.
小型猪是一种有用的大动物实验模型。小型猪的各种组织和器官在发育、解剖、免疫和生理特征方面与人类相似。小型猪的口腔颌面区域常用于再生牙科的临床前研究。然而，关于小型猪的牙齿和牙结构的信息有限。本研究旨在通过使用软 X 射线进行二维观察和微 CT 进行三维观察的 X 射线分析，研究小型猪下颌颊齿的牙列和牙结构（特别是牙根）的时程变化。使用雄性克劳恩（Claw）品系小型猪（2 周和 3、5、7、9、11、14、17 和 29 月龄）的下颌骨。小型猪颊齿的 X 射线分析表明，小型猪的出牙模式是双牙型，替换模式是垂直型。先前关于乳牙和恒牙的定义经常变化，而且关于牙齿（牙列）的数量也没有共识；然而，我们发现乳牙有 3 个磨牙，恒牙有 4 个前磨牙和 3 个磨牙。此外，我们还证实了牙齿根和根管的数量。我们相信这些发现将在未来使用小型猪牙齿的研究中非常有用。
