Departments of Endocrinology, Neurology and Radiology, Medway Maritime Hospital, c/o Diabetes Centre, Residence 9, Gillingham, ME7 5NY, UK,
Endocrine. 2014 Feb;45(1):9-14. doi: 10.1007/s12020-013-9991-1. Epub 2013 Jun 8.
Considerable evidence attests to the role of the hypothalamic-pituitary endocrine axis (HPA) in the maintenance of normal immunocompetence. The immune and neuroendocrine systems are integrally linked and coordinated with bidirectional communication maintaining immune balance. Any disturbance of the normal function of the HPA may significantly alter native immunocompetence and therefore be associated with the development of disorders which have a clearly established autoimmune basis. Molecular and functional evidence shows prolactin, produced by the anterior pituitary, to be a cytokine, exerting its effect via both paracrine and endocrine mechanisms [1]. Its involvement in the activation of multiple immune responses may adversely upregulate certain autoimmune diseases. Myasthenia gravis (MG) has long been recognized as an autoimmune disorder. In this mini review, we present the coterminous presentation of MG and prolactin-secreting macroadenoma. We review published cases in the world literature, discuss pathological mechanism, and consider future targeted therapies.
大量证据证明下丘脑-垂体内分泌轴 (HPA) 在维持正常免疫功能方面的作用。免疫和神经内分泌系统是紧密相连的，并通过双向通讯进行协调，以维持免疫平衡。HPA 的正常功能任何干扰都可能显著改变天然免疫功能，因此可能与具有明确自身免疫基础的疾病的发展有关。分子和功能证据表明，由垂体前叶产生的催乳素是一种细胞因子，通过旁分泌和内分泌机制发挥作用[1]。它参与多种免疫反应的激活可能会不利地上调某些自身免疫性疾病。重症肌无力 (MG) 长期以来一直被认为是一种自身免疫性疾病。在这个小型综述中，我们提出了 MG 和催乳素分泌大腺瘤同时出现的情况。我们复习了世界文献中的已发表病例，讨论了病理机制，并考虑了未来的靶向治疗。
