Graduate Entry Medicine, University of Nottingham, Derby, UK
Endocrinology, United Lincolnshire Hospitals NHS Trust, Boston, Lincolnshire, UK.
BMJ Case Rep. 2020 Dec 17;13(12):e234322. doi: 10.1136/bcr-2020-234322.
Myasthenia gravis (MG) is a rare and potentially dangerous autoimmune condition, which affects the acetylcholine receptors at the neuromuscular junction of skeletal muscle. MG's diverse symptomatology may readily masquerade as other neurological conditions, posing a diagnostic challenge to clinicians. We describe a 24-year old man who presented to the emergency department with a new onset internuclear ophthalmoplegia. After a series of investigations, we eventually arrived at a diagnosis of MG with pseudointernuclear ophthalmoplegia with an incidentally detected prolactinoma. We explore the literature regarding the pathophysiology of pseudointernuclear ophthalmoplegia, the link between prolactin and autoimmunity and the association between prolactinoma and MG.
重症肌无力（MG）是一种罕见且潜在危险的自身免疫性疾病，影响骨骼肌神经肌肉接头处的乙酰胆碱受体。MG 的多种症状可能很容易伪装成其他神经疾病，给临床医生的诊断带来挑战。我们描述了一位 24 岁的男性，他因新发核间性眼肌麻痹而到急诊科就诊。经过一系列检查，我们最终诊断为伴有偶然发现的泌乳素瘤的假性核间性眼肌麻痹性 MG。我们探讨了关于假性核间性眼肌麻痹的发病机制、泌乳素与自身免疫之间的联系以及泌乳素瘤与 MG 之间的关联的文献。
