人工二尖瓣血栓形成的成功溶栓治疗。
Successful thrombolytic treatment of prosthetic mitral valve thrombosis.
作者信息
Gazi Emine, Altun Burak, Temiz Ahmet, Colkesen Yucel
机构信息
Department of Cardiology, Canakkale Onsekiz Mart University, Canakkale, Turkey.
出版信息
BMJ Case Rep. 2013 Jun 7;2013:bcr2013009917. doi: 10.1136/bcr-2013-009917.
Abstract
Prosthetic heart valve thrombosis is a rare but serious complication. Surgery is the first-line therapy in symptomatic obstructive mechanical valve thrombosis, thrombolytic therapy has been used as an alternative to surgical treatment. In this case report we described a 47-year-old woman who had undergone coronary artery bypass graft and mitral valve replacement operation 9 months ago. A thrombus was detected on the prosthetic mitral valve with high transmitral gradient by transoesophageal echocardiography. Tissue plasminogen activator treatment was administered successfully. The gradient was improved on prosthetic mitral valve and embolic complications or bleeding were not occurred.
摘要
人工心脏瓣膜血栓形成是一种罕见但严重的并发症。手术是有症状的梗阻性机械瓣膜血栓形成的一线治疗方法，溶栓治疗已被用作手术治疗的替代方法。在本病例报告中，我们描述了一名47岁的女性，她在9个月前接受了冠状动脉搭桥术和二尖瓣置换手术。经食管超声心动图检查发现人工二尖瓣上有血栓，二尖瓣跨瓣压差较高。成功给予组织纤溶酶原激活剂治疗。人工二尖瓣的压差得到改善，未发生栓塞并发症或出血。
相似文献
1
Successful thrombolytic treatment of prosthetic mitral valve thrombosis.人工二尖瓣血栓形成的成功溶栓治疗。
BMJ Case Rep. 2013 Jun 7;2013:bcr2013009917. doi: 10.1136/bcr-2013-009917.
2
Use of transesophageal echocardiography during thrombolysis with tissue plasminogen activator of a thrombosed prosthetic mitral valve.在使用组织型纤溶酶原激活剂对人工机械二尖瓣血栓形成进行溶栓治疗期间行经食管超声心动图检查。
J Am Soc Echocardiogr. 1992 Mar-Apr;5(2):153-8. doi: 10.1016/s0894-7317(14)80545-2.
3
A rare cause of myocardial infarction: acute inferoposterior myocardial infarction after successful intravenous thrombolytic treatment of mechanical mitral prosthetic valve thrombosis.心肌梗死的罕见病因：机械性二尖瓣人工瓣膜血栓形成经静脉溶栓治疗成功后发生的急性下后壁心肌梗死。
Int J Cardiovasc Imaging. 2005 Oct;21(5):509-12. doi: 10.1007/s10554-004-8331-1.
4
Thrombolysis for obstructed CarboMedics mitral valve prosthesis.
Ann Thorac Surg. 1995 Feb;59(2):509-11. doi: 10.1016/0003-4975(94)00585-u.
5
[A successful thrombolytic therapy for thrombosed ATS valve in the mitral position in a child; report of a case].
Kyobu Geka. 2003 Aug;56(9):790-2.
6
Thrombolytic therapy of a left-sided prosthetic valve thrombosis without hemodynamic obstruction: a case report.左侧人工瓣膜血栓形成且无血流动力学障碍的溶栓治疗：一例报告
J Am Soc Echocardiogr. 2001 Dec;14(12):1230-4. doi: 10.1067/mje.2001.114396.
7
Successful Fibrinolytic Therapy in a Challenging Obstructive Prosthetic Mitral Valve Thrombosis.成功溶栓治疗极具挑战性的人工机械二尖瓣血栓形成
J Investig Med High Impact Case Rep. 2020 Jan-Dec;8:2324709620921078. doi: 10.1177/2324709620921078.
8
Intravenous thrombolytic treatment of mechanical prosthetic valve thrombosis: a study using serial transesophageal echocardiography.机械人工瓣膜血栓形成的静脉溶栓治疗：一项使用连续经食管超声心动图的研究
J Am Coll Cardiol. 2000 Jun;35(7):1881-9. doi: 10.1016/s0735-1097(00)00654-9.
9
Thrombolytic treatment of prosthetic valve thrombosis: a study using Urokinase.人工瓣膜血栓的溶栓治疗：使用尿激酶的研究。
J Cardiothorac Surg. 2020 Oct 1;15(1):286. doi: 10.1186/s13019-020-01324-7.
10
An unusual thrombolytic therapy decision in prosthetic valve thrombosis during early pregnancy.妊娠早期人工瓣膜血栓形成时一个不同寻常的溶栓治疗决策。
Turk Kardiyol Dern Ars. 2015 Sep;43(6):554-7. doi: 10.5543/tkda.2015.68327.
引用本文的文献
1
A particular appearance of a diaphragm pannus completely masking a mechanical mitral valve: a case report.一例完全掩盖机械二尖瓣的膈肌血管翳特殊表现：病例报告
Pan Afr Med J. 2025 Apr 30;50:115. doi: 10.11604/pamj.2025.50.115.47267. eCollection 2025.
2
Successful management of recurrent thrombosis of prosthetic mitral valve induced by eosinophilia secondary to parasitic infection.寄生虫感染继发嗜酸性粒细胞增多所致人工二尖瓣复发性血栓形成的成功管理。
BMJ Case Rep. 2025 Jun 30;18(6):e265654. doi: 10.1136/bcr-2025-265654.
3
Fibrinolytic Treatment after Transient Ischaemic Attack Caused by Prosthetic Mitral Valve Thrombosis.人工二尖瓣血栓形成所致短暂性脑缺血发作后的纤溶治疗。
Case Rep Cardiol. 2016;2016:6809263. doi: 10.1155/2016/6809263. Epub 2016 May 26.
本文引用的文献
1
Guidelines on the management of valvular heart disease (version 2012).心脏瓣膜病管理指南（2012年版）
Eur Heart J. 2012 Oct;33(19):2451-96. doi: 10.1093/eurheartj/ehs109. Epub 2012 Aug 24.
2
Early post-operative thrombosis of the prosthetic mitral valve in patient with heparin-induced thrombocytopenia.肝素诱导的血小板减少症患者人工二尖瓣术后早期血栓形成
J Cardiothorac Surg. 2012 Mar 13;7:23. doi: 10.1186/1749-8090-7-23.
3
Comparison of fibrinolytic versus surgical therapy in the treatment of obstructive prosthetic valve thrombosis: a single-center experience.纤维蛋白溶解疗法与手术疗法治疗人工瓣膜阻塞性血栓形成的比较：单中心经验
Heart Surg Forum. 2011 Apr;14(2):E87-92. doi: 10.1532/HSF98.20101062.
4
Two cases of valvular thrombosis secondary to heparin-induced thrombocytopenia managed without surgery.
Circulation. 2011 Mar 29;123(12):1355-7. doi: 10.1161/CIRCULATIONAHA.110.966523.
5
Comparison of thrombolysis versus surgery as a first line therapy for prosthetic heart valve thrombosis.比较心脏机械瓣膜血栓形成时溶栓治疗与手术治疗作为一线治疗的差异。
Am J Cardiol. 2011 Jan 15;107(2):275-9. doi: 10.1016/j.amjcard.2010.09.013.
6
Management of prosthetic heart valve obstruction: fibrinolysis versus surgery. Early results and long-term follow-up in a single-centre study of 263 cases.人工心脏瓣膜梗阻的处理：纤溶治疗与手术治疗。一项针对263例患者的单中心研究的早期结果及长期随访
Arch Cardiovasc Dis. 2009 Apr;102(4):269-77. doi: 10.1016/j.acvd.2009.01.007. Epub 2009 Apr 8.
7
Improving the quality of anticoagulant therapy in patients with mechanical heart valves: what are we waiting for?
Eur Heart J. 2007 Oct;28(20):2424-6. doi: 10.1093/eurheartj/ehm405. Epub 2007 Sep 22.
8
Thrombolysis as first choice therapy in prosthetic heart valve thrombosis. A study of 68 patients.溶栓作为人工心脏瓣膜血栓形成的首选治疗方法。一项对68例患者的研究。
J Thromb Thrombolysis. 2006 Apr;21(2):185-90. doi: 10.1007/s11239-006-4969-y.
9
Prosthetic heart valve thrombosis: pathogenesis, diagnosis and management.人工心脏瓣膜血栓形成：发病机制、诊断与管理
Int J Cardiol. 2006 Jun 7;110(1):1-6. doi: 10.1016/j.ijcard.2005.06.051. Epub 2005 Jul 20.
10
Transesophageal echocardiography improves risk assessment of thrombolysis of prosthetic valve thrombosis: results of the international PRO-TEE registry.经食管超声心动图可改善人工瓣膜血栓形成溶栓治疗的风险评估：国际PRO-TEE注册研究结果
J Am Coll Cardiol. 2004 Jan 7;43(1):77-84. doi: 10.1016/j.jacc.2003.08.028.
Zotero 插件