Department of Physiology, Medical School, National and Kapodistian University of Athens, Athens, Greece.
Anticancer Res. 2013 Jun;33(6):2441-5.
Recent evidence suggests a role for the insulin-like growth factor-1Ec (IGF-IEc) transcript variant in cancer biology. The aim of the present study was to investigate whether IGF-IEc expression is associated with prostate cancer stage.
Formalin-fixed and paraffin-embedded prostate cancer surgical specimens from 83 patients were assessed by immunohistochemistry for IGF-IEc expression.
Normal prostate epithelium was negative or demonstrated mild IGF-IEc cytoplasmic expression whereas prostate cancer exhibited mild to strong cytoplasmic immunoexpression. The mean IGF-1Ec expression, was significantly lower (p=0.004) in localized (stage ≤ IIb) prostate cancer, compared to locally advanced tumors (stage ≥ III). Only one out of 83 (1.2%) prostate cancer samples was completely negative for IGF-IEc. A weak-positive correlation was also observed between IGF-IEc expression levels and Gleason score (r=0.247; p=0.024).
The present data demonstrate that the expression of IGF-IEc is positively-associated with more advanced stage and higher Gleason score of prostate carcinomas.
最近的证据表明胰岛素样生长因子-1Ec（IGF-IEc）转录变体在癌症生物学中具有作用。本研究旨在探讨 IGF-IEc 表达是否与前列腺癌分期相关。
对 83 例前列腺癌手术标本进行福尔马林固定和石蜡包埋，通过免疫组织化学法检测 IGF-IEc 的表达。
正常前列腺上皮呈阴性或显示轻度 IGF-IEc 细胞质表达，而前列腺癌呈轻度至强的细胞质免疫表达。与局部进展性肿瘤（≥III 期）相比，局限性（≤IIb 期）前列腺癌的平均 IGF-1Ec 表达显著降低（p=0.004）。83 例前列腺癌样本中只有 1 例（1.2%）完全缺乏 IGF-IEc。IGF-IEc 表达水平与 Gleason 评分之间也存在弱正相关（r=0.247；p=0.024）。
本研究数据表明，IGF-IEc 的表达与前列腺癌的更晚期和更高的 Gleason 评分呈正相关。
