Department of Surgery at the Institute of Clinical Sciences, The Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital/Ostra, Gothenburg, Sweden.
Anticancer Res. 2013 Jun;33(6):2447-51.
The enzyme thymidine phosphorylase (TYMP) has tumor-promoting functions and its expression is often elevated in tumors.
TYMP gene expression in tumorous and mucosal tissues was assessed using real-time polymerase chain reaction, in a study of patients with rectal cancer where chemotherapy and radiotherapy were given sequentially.
TYMP levels decreased after chemotherapy. For patients given radiotherapy, there was a significant increase in TYMP expression comparing biopsies before and after radiotherapy. The increase was also observed in the mucosa, although it was less pronounced.
Cancer treatment alters gene expression in tumor and adjacent mucosa of patients with rectal cancer. Chemotherapy may cause a decrease in TYMP gene expression, whereas radiotherapy, given as adjuvant treatment, causes a significant increase in expression. These results are of importance when interpreting TYMP expression data in rectal cancer and may be of clinical interest as TYMP participates in the activation of capecitabine.
胸苷磷酸化酶（TYMP）具有促进肿瘤的功能，其表达通常在肿瘤中升高。
使用实时聚合酶链反应评估直肠癌患者肿瘤和黏膜组织中的 TYMP 基因表达，这些患者接受了序贯化疗和放疗。
化疗后 TYMP 水平下降。对于接受放疗的患者，与放疗前相比，放疗后活检中 TYMP 表达显著增加。在黏膜中也观察到这种增加，尽管程度较轻。
直肠癌患者的癌症治疗会改变肿瘤和相邻黏膜中的基因表达。化疗可能导致 TYMP 基因表达减少，而作为辅助治疗的放疗则导致表达显著增加。这些结果在解释直肠癌中 TYMP 表达数据时很重要，并且由于 TYMP 参与卡培他滨的激活，因此可能具有临床意义。
