Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Anticancer Res. 2013 Jun;33(6):2517-24.
Chemical synthesis and characterization of a lipophilic ester conjugate, propofol stearate and evaluation of its anticancer efficacy on human breast cancer cell lines MDA-MB-361, MCF-7 and MDA-MB-231.
The chemical structure of the synthesized conjugate was characterized by spectroscopic studies. Its anticancer potential was evaluated on the basis of growth inhibition, cancer cell adhesion and migration and apoptosis induction.
Propofol stearate exhibited significant (p<0.05) growth inhibition of breast cancer cells in a concentration-dependent manner. MDA-MB-231 cells showed highest susceptibility towards the inhibitory effect of the conjugate. Moreover, treatment of MDA-MB-231 cancer cells with 25 μM propofol stearate potentially suppressed their adhesion (34%) and migration (41%), and induced apoptosis (~25%).
Exogenously-applied stearic acid as an ester derivative, inhibits the growth of human breast cancer cells and shows a beneficial role in the treatment of breast cancer, in vitro.
合成一种亲脂性酯缀合物——丙泊酚硬脂酸酯，并对其在人乳腺癌细胞系 MDA-MB-361、MCF-7 和 MDA-MB-231 中的抗癌功效进行评估。
通过光谱研究对合成缀合物的化学结构进行了表征。基于生长抑制、癌细胞黏附和迁移以及细胞凋亡诱导，评估其抗癌潜力。
丙泊酚硬脂酸酯以浓度依赖的方式显著（p<0.05）抑制乳腺癌细胞的生长。MDA-MB-231 细胞对该缀合物的抑制作用最为敏感。此外，用 25 μM 丙泊酚硬脂酸酯处理 MDA-MB-231 癌细胞可潜在抑制其黏附和迁移（34%和41%），并诱导细胞凋亡（~25%）。
外源性硬脂酸作为酯衍生物，可抑制人乳腺癌细胞的生长，并在体外对乳腺癌的治疗具有有益作用。
