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严重维拉帕米（缓释制剂）过量。

Severe verapamil (sustained-release) overdose.

作者信息

Krick S E, Gums J G, Grauer K, Cooper G R

机构信息

Medical College of Virginia.

出版信息

DICP. 1990 Jul-Aug;24(7-8):705-6. doi: 10.1177/106002809002400711.

DOI:10.1177/106002809002400711
PMID:2375141
Abstract

Vasodilators, specifically calcium-channel modulators, are currently in widespread use for the treatment of essential hypertension. Several reports of toxicity from immediate-release verapamil have appeared in the literature. We present a case of sustained-release verapamil overdose as a consequence of an attempted suicide. The treatment measures used in a verapamil toxicity are discussed, as well as a review of the current literature on verapamil overdose.

摘要

血管扩张剂，特别是钙通道调节剂，目前广泛用于治疗原发性高血压。文献中已出现数例关于速释维拉帕米毒性的报道。我们报告一例因企图自杀导致的缓释维拉帕米过量病例。文中讨论了维拉帕米中毒时所采用的治疗措施，并对当前有关维拉帕米过量的文献进行了综述。

相似文献

1
Severe verapamil (sustained-release) overdose.严重维拉帕米（缓释制剂）过量。
DICP. 1990 Jul-Aug;24(7-8):705-6. doi: 10.1177/106002809002400711.
2
Massive overdose of sustained-release verapamil: a case report and review of literature.缓释维拉帕米大量过量：一例病例报告及文献综述
Am J Med Sci. 1995 Dec;310(6):258-63.
3
Case report: fatal overdose with sustained-release verapamil.病例报告：缓释维拉帕米致死性过量服用。
Am J Med Sci. 1992 Feb;303(2):115-7. doi: 10.1097/00000441-199202000-00011.
4
Delayed onset of cardiac arrhythmias from sustained-release verapamil.
Ann Emerg Med. 1991 Feb;20(2):201-3. doi: 10.1016/s0196-0644(05)81224-7.
5
Intravenous fat emulsion therapy for intentional sustained-release verapamil overdose.静脉脂肪乳剂治疗维拉帕米缓释制剂故意过量服用。
Resuscitation. 2009 May;80(5):591-3. doi: 10.1016/j.resuscitation.2009.01.023. Epub 2009 Mar 17.
6
Overdose of sustained-release verapamil.
Br J Anaesth. 1994 Mar;72(3):361-5. doi: 10.1093/bja/72.3.361.
7
Delayed hypotension after overdose of sustained release verapamil.缓释维拉帕米过量后迟发性低血压
J Emerg Med. 1994 Sep-Oct;12(5):621-5. doi: 10.1016/0736-4679(94)90414-6.
8
Poisoning with sustained-release verapamil.缓释维拉帕米中毒
Am J Med. 1988 Jul;85(1):127. doi: 10.1016/0002-9343(88)90522-0.
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[Overdose of a drug with delayed action].
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引用本文的文献

1
Prolonged half-life of verapamil in a case of overdose: implications for therapy.维拉帕米过量病例中半衰期延长：对治疗的启示
Br J Clin Pharmacol. 1995 Jun;39(6):680-3. doi: 10.1111/j.1365-2125.1995.tb05729.x.
2
Poisoning due to calcium antagonists. Experience with verapamil, diltiazem and nifedipine.钙拮抗剂中毒。维拉帕米、地尔硫䓬和硝苯地平的经验
Drug Saf. 1991 Nov-Dec;6(6):408-30. doi: 10.2165/00002018-199106060-00003.