维拉帕米过量病例中半衰期延长：对治疗的启示
Prolonged half-life of verapamil in a case of overdose: implications for therapy.
作者信息
Buckley C D, Aronson J K
机构信息
Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, UK.
出版信息
Br J Clin Pharmacol. 1995 Jun;39(6):680-3. doi: 10.1111/j.1365-2125.1995.tb05729.x.
Abstract
After an overdose of verapamil (2.4 g) in a 59-year-old man the apparent half-life of verapamil was prolonged (15 h). The most likely mechanism is rate-limiting absorption, although changes in clearance and volume of distribution may contribute. As the elimination half-life of verapamil is increased in overdose, therapy may have to be continued for longer than expected. Moreover since the half-life of absorption of verapamil in overdose may be prolonged, activated charcoal should be given in repeated doses, even if an ordinary-release formulation has been taken.
摘要
一名59岁男性过量服用维拉帕米（2.4克）后，维拉帕米的表观半衰期延长（15小时）。最可能的机制是吸收限速，尽管清除率和分布容积的变化可能也有作用。由于过量服用时维拉帕米的消除半衰期增加，治疗可能需要比预期更长的时间。此外，由于过量服用时维拉帕米的吸收半衰期可能延长，即使服用的是普通释放制剂，也应重复给予活性炭。
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