Uvaraj Periasamy, Rathisharmila Ramar, Ilamaran Veerappan
Melmaruvathur Adhiparasakthi Institute of Medical Sciences and Research, Tamilnadu, India.
Blood Coagul Fibrinolysis. 2013 Sep;24(6):652-4. doi: 10.1097/MBC.0b013e3283609972.
Protein C and S are vitamin K-dependent natural anticoagulants. They play a major role in hemostasis by degrading the activated factor V and factor VIII. Deficiencies of protein C and protein S are associated with increased risk of thrombotic events. The combined occurrence of protein C and S deficiency has been rarely reported. We report a 6-year-old boy with Budd-Chiari syndrome due to combined protein C and protein S deficiency. He was managed with low molecular weight heparin and discharged on long-term warfarin therapy.
蛋白C和蛋白S是维生素K依赖的天然抗凝剂。它们通过降解活化的因子V和因子VIII在止血过程中发挥主要作用。蛋白C和蛋白S缺乏与血栓形成事件风险增加相关。蛋白C和S联合缺乏的情况鲜有报道。我们报告了一名6岁男孩，因蛋白C和蛋白S联合缺乏患有布加综合征。他接受了低分子量肝素治疗，并在长期华法林治疗后出院。
