Baker J J, Solanki P H, Schenk D A, Van Pelt C, Ramzy I
Department of Pathology, Willford Hall USAF Medical Center, Lackland Air Force Base, Texas.
Acta Cytol. 1990 Jul-Aug;34(4):517-23.
To determine the effectiveness and accuracy of transbronchial fine needle aspiration of mediastinal masses for the staging of bronchogenic carcinoma, the results and histologic correlations of 97 transbronchial aspirates submitted from 78 patients over a two-year period were reviewed. Malignant cells were present in 25 of 97 aspirates. Of the remaining 75 nonmalignant aspirates, 34 had corresponding mediastinal tissue sections. Review of these 34 aspirates disclosed respiratory epithelial cells without lymphocytes in 20, lymphocytes without respiratory cells in 1 and both cell types in 8. Neither cell type was present in five aspirates. The predictive value of a negative result was 78% for nonmalignant aspirates containing lymphocytes and 36% for nonmalignant aspirates not containing lymphocytes (P less than .05). The presence of lymphocytes in transbronchial needle aspirates of the mediastinum is an essential criterion of specimen adequacy. Negative specimens lacking lymphocytes should be considered unsatisfactory, regardless of the numbers of respiratory epithelial cells present.
为了确定经支气管细针穿刺纵隔肿块用于支气管源性癌分期的有效性和准确性，我们回顾了两年期间78例患者提交的97份经支气管穿刺抽吸物的结果及组织学相关性。97份抽吸物中有25份存在恶性细胞。在其余75份非恶性抽吸物中，34份有相应的纵隔组织切片。对这34份抽吸物的检查发现，20份有呼吸上皮细胞但无淋巴细胞，1份有淋巴细胞但无呼吸细胞，8份两种细胞类型都有。5份抽吸物中两种细胞类型均未出现。对于含有淋巴细胞的非恶性抽吸物，阴性结果的预测价值为78%，对于不含有淋巴细胞的非恶性抽吸物，阴性结果的预测价值为36%（P小于0.05）。纵隔经支气管针吸物中淋巴细胞的存在是标本充分性的重要标准。无论存在多少呼吸上皮细胞，缺乏淋巴细胞的阴性标本都应被视为不充分。
