Departamento de Medicina y Patología Oral y Maxilofacial, Facultad de Odontología, Univ de San Martín de Porres-USMP, Lima, Peru.
Braz Oral Res. 2013 Jul-Aug;27(4):349-55. doi: 10.1590/S1806-83242013005000018. Epub 2013 Jun 11.
The purpose of this study was to determine the survival and prognostic factors of patients with diffuse large B-cell lymphoma (DLBCL) of the oral cavity and maxillofacial region. Retrospectively, the clinical records of patients with a primary diagnosis of DLBCL of the oral cavity and maxillofacial region treated at the A.C. Camargo Hospital for Cancer, São Paulo, Brazil, between January 1980 and December 2005 were evaluated to determine (A) overall survival (OS) at 2 and 5 years and the individual survival percentage for each possible prognostic factor by means of the actuarial technique (also known as mortality tables), and the Kaplan Meier product limit method (which provided the survival value curves for each possible prognostic factor); (B) prognostic factors subject to univariate evaluation with the log-rank test (also known as Mantel-Cox), and multivariate analysis with Cox's regression model (all the variables together). The data were considered significant at p≤0.05. From 1980 to 2005, 3513 new cases of lymphomas were treated, of which 151 (4.3%) occurred in the oral cavity and maxillofacial region. Of these 151 lesions, 48 were diffuse large B-cell lymphoma, with 64% for OS at 2 years and 45% for OS at 5 years. Of the variables studied as possible prognostic factors, multivariate analysis found the following variables have statistically significant values: age (p=0.042), clinical stage (p=0.007) and performance status (p=0.031). These data suggest that patients have a higher risk of mortality if they are older, at a later clinical stage, and have a higher performance status.
本研究旨在确定口腔和颌面区域弥漫性大 B 细胞淋巴瘤（DLBCL）患者的生存和预后因素。回顾性分析了 1980 年 1 月至 2005 年 12 月在巴西圣保罗 A.C.Camargo 癌症医院接受治疗的口腔和颌面区域原发性 DLBCL 患者的临床记录，以确定（A）通过 actuarial 技术（也称为死亡率表）和 Kaplan-Meier 乘积限法（为每个可能的预后因素提供生存值曲线）评估 2 年和 5 年的总生存率（OS）以及每个可能的预后因素的个体生存率百分比；（B）通过对数秩检验（也称为 Mantel-Cox）进行单变量评估和 Cox 回归模型的多变量分析（所有变量一起）的预后因素。数据被认为在 p≤0.05 时具有统计学意义。1980 年至 2005 年间，共治疗了 3513 例新的淋巴瘤患者，其中 151 例（4.3%）发生在口腔和颌面区域。在这 151 例病变中，有 48 例为弥漫性大 B 细胞淋巴瘤，2 年 OS 率为 64%，5 年 OS 率为 45%。在研究的作为可能预后因素的变量中，多变量分析发现以下变量具有统计学意义：年龄（p=0.042）、临床分期（p=0.007）和表现状态（p=0.031）。这些数据表明，如果患者年龄较大、处于较晚的临床分期和表现状态较高，其死亡风险更高。
