白细胞介素 23 受体基因多态性与中国人群系统性红斑狼疮无关。
Lack of association between IL-23R gene polymorphisms and systemic lupus erythematosus in a Chinese population.
机构信息
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, People's Republic of China.
出版信息
Inflamm Res. 2013 Aug;62(8):791-5. doi: 10.1007/s00011-013-0636-x. Epub 2013 Jun 11.
OBJECTIVE
The aim to this study was to investigate the association between the single-nucleotide polymorphisms (SNPs) of interleukin (IL)-23 receptor gene and systemic lupus erythematosus (SLE) in a Chinese population.
METHODS
A case-control study was performed to investigate the associations of SNPs in IL-23R gene (rs10889677 and rs1884444) with susceptibility to SLE in 521 Chinese SLE patients and 527 normal controls. The chi-square test and unconditional Logistic regression were used to analysis by SPSS 10.1 software.
RESULTS
No significant differences were detected for the distribution of allele and genotype frequencies of these two SNPs between patients and controls as well as SLE patients with nephritis (LN) and those without nephritis.
CONCLUSION
The findings suggest that the polymorphisms of IL-23R gene might not contribute to the susceptibility of SLE in the Chinese population.
目的
本研究旨在探讨白细胞介素（IL）-23 受体基因单核苷酸多态性（SNPs）与中国人群系统性红斑狼疮（SLE）之间的关系。
方法
采用病例对照研究方法，检测 IL-23R 基因（rs10889677 和 rs1884444）的 SNPs 与 521 例中国 SLE 患者和 527 例正常对照者易感性的相关性。采用 SPSS 10.1 软件进行 χ2 检验和非条件 Logistic 回归分析。
结果
未发现这两个 SNP 的等位基因和基因型频率在患者和对照组以及有肾炎（LN）和无肾炎的 SLE 患者之间存在分布差异。
结论
这些发现表明，IL-23R 基因的多态性可能不会导致中国人群 SLE 的易感性。
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