Zhao Xue-Fei, Pan Hai-Feng, Yuan Hui, Zhang Wen-Hui, Li Xiang-Pei, Wang Gui-Hong, Wu Guo-Cui, Su Hong, Pan Fa-Ming, Li Wen-Xian, Li Lian-Hong, Chen Guo-Ping, Ye Dong-Qing
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Anhui, People's Republic of China.
Mol Biol Rep. 2010 Jan;37(1):81-5. doi: 10.1007/s11033-009-9533-3. Epub 2009 Apr 4.
Interleukin 17 (IL-17) is a Th17 cytokine associated with inflammation, autoimmunity and defense against some bacteria, it has been implicated in many chronic autoimmune diseases including psoriasis, multiple sclerosis and systemic sclerosis. However, whether IL-17 plays a role in the pathogenesis of systemic lupus erythematosus (SLE) remains unclear. In the present study, we aimed to investigate the serum IL-17 level in patients with SLE and it's associations with disease manifestations and activity. Fifty-seven patients with SLE and 30 healthy volunteers were recruited. Serum IL-17 levels were examined by enzyme linked immunosorbent assay (ELISA). Statistic analyzes were performed by SPSS 10.01. Results show that serum IL-17 levels were significantly elevated in SLE patients as compared with normal controls. Nevertheless, no associations of serum IL-17 level with clinical and laboratory parameters were found; no significant difference regarding serum IL-17 level between SLE patients with nephritis and those without nephritis was found; no significant difference was found between Less active SLE and More active SLE; Correlation analysis between serum IL-17 levels and SLEDAI showed no association. Taken together, our results indicate increased serum IL-17 levels in SLE patients, suggesting that this cytokine may trigger the inflammatory process in SLE. However, no associations of serum IL-17 level with disease manifestations were found. Therefore, further studies are required to confirm this preliminary data.
白细胞介素17（IL-17）是一种与炎症、自身免疫及抵抗某些细菌有关的Th17细胞因子，它与许多慢性自身免疫性疾病有关，包括银屑病、多发性硬化症和系统性硬化症。然而，IL-17是否在系统性红斑狼疮（SLE）的发病机制中起作用仍不清楚。在本研究中，我们旨在调查SLE患者的血清IL-17水平及其与疾病表现和活动的相关性。招募了57例SLE患者和30名健康志愿者。采用酶联免疫吸附测定（ELISA）检测血清IL-17水平。使用SPSS 10.01进行统计分析。结果显示，与正常对照组相比，SLE患者的血清IL-17水平显著升高。然而，未发现血清IL-17水平与临床和实验室参数之间存在相关性；在有肾炎的SLE患者和无肾炎的SLE患者之间，血清IL-17水平未发现显著差异；在病情较轻的SLE患者和病情较重的SLE患者之间未发现显著差异；血清IL-17水平与SLE疾病活动指数（SLEDAI）之间的相关性分析未显示存在关联。综上所述，我们的结果表明SLE患者血清IL-17水平升高，提示这种细胞因子可能触发SLE中的炎症过程。然而，未发现血清IL-17水平与疾病表现之间存在关联。因此，需要进一步研究来证实这些初步数据。
