Karimi Parisa, Modarresi Seyedeh Zalfa, Sahraian Mohammad Ali, Shokouhi Shoormasti Raheleh, Mahlooji Maryam, Kazemnejad Anoushirvan, Pourpak Zahra
Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Iran J Allergy Asthma Immunol. 2013 May 15;12(2):182-9.
Multiple Sclerosis (MS) and Allergy are believed to up regulate T helper cell type 1 (Th1) and T helper cell type 2 (Th2) responses, respectively. It has been shown that disequilibrium in the ratio of Th1/Th2 activities may increase frequency of one disease and decrease the frequency of the other. The aim of this study was to investigate the relation of MS with allergy and atopy in new diagnosed MS patients. This case-control study was conducted on 40 new diagnosed MS patients and the same number of normal controls. All of the patients were diagnosed (according to McDonald criteria) at most 2 years prior to the study. Demographic data and clinical characteristics of both groups were recorded in a questionnaire. The total IgE and allergen specific IgE in the serum were measured in all the cases. Forty MS patients (female/male: 4.71) with mean age of 30.55±9.5 years and 40 healthy controls entered in this study. History of allergy was observed in 20(50%) of MS patients (including 15 (37.5%) rhinitis, 6 (15%) conjunctivitis, 3 (7.5%) urticaria and eczema, 1 (2.5%) asthma), and 20 (50%) of the controls (including 8 (20%) rhinitis, 4 (10%) conjunctivitis, 7 (17.5%) urticaria and eczema, 1 (2.5%) asthma). The differences between the two groups were not statistically significant. Neither the serum total IgE, nor the frequency of specific IgE against Weed mix, Grass Mix, Tree mix1, Tree mix 2, Dermatophagoides Farinae, Dermatophagoides pteronyssinus and Epidermal and animal proteins mix differed statistically between the two groups. There was also no significant relationship between MS clinical manifestations and allergy prevalence and also between MS and atopy. The results of this study as some other similar studies showed the same prevalence of allergy in MS patients and controls and also demonstrated no relation between MS and atopy.
多发性硬化症（MS）和过敏反应分别被认为会上调1型辅助性T细胞（Th1）和2型辅助性T细胞（Th2）反应。研究表明，Th1/Th2活性比例失衡可能会增加一种疾病的发病率，同时降低另一种疾病的发病率。本研究旨在调查新诊断的MS患者中MS与过敏及特应性之间的关系。本病例对照研究选取了40例新诊断的MS患者和相同数量的正常对照。所有患者均在研究前最多2年被诊断（根据麦克唐纳标准）。两组的人口统计学数据和临床特征通过问卷记录。对所有病例检测血清中的总IgE和过敏原特异性IgE。40例MS患者（女性/男性：4.71），平均年龄30.55±9.5岁，以及40例健康对照纳入本研究。20例（50%）MS患者有过敏史（包括15例（37.5%）鼻炎、6例（15%）结膜炎、3例（7.5%）荨麻疹和湿疹、1例（2.5%）哮喘），20例（50%）对照有过敏史（包括8例（20%）鼻炎、4例（10%）结膜炎、7例（17.5%）荨麻疹和湿疹、1例（2.5%）哮喘）。两组之间的差异无统计学意义。两组血清总IgE以及针对杂草混合物、草混合物、树混合物1、树混合物2、粉尘螨、屋尘螨以及表皮和动物蛋白混合物的特异性IgE频率在统计学上均无差异。MS临床表现与过敏患病率之间以及MS与特应性之间也无显著关系。本研究结果与其他一些类似研究一样，显示MS患者和对照中过敏患病率相同，并且也表明MS与特应性之间无关联。
