Department of Internal Medicine, University of Manitoba, Winnipeg, Canada/Department of Community Health Sciences, University of Manitoba, Winnipeg, Canada
Department of Internal Medicine, University of Manitoba, Winnipeg, Canada.
Mult Scler. 2015 Mar;21(3):332-41. doi: 10.1177/1352458514564488. Epub 2014 Dec 23.
As new disease-modifying therapies emerge a better knowledge of the risk of comorbid disease in multiple sclerosis (MS) is needed.
To estimate the incidence and prevalence of comorbid gastrointestinal, musculoskeletal, ocular, pulmonary, and renal disorders in MS.
We systematically reviewed the world literature by searching PUBMED, EMBASE, SCOPUS, the Web of Knowledge, and reference lists of retrieved articles. For selected articles, one reviewer abstracted data using a standardized form. The abstraction was verified by a second reviewer. The quality of all selected studies was assessed. For population-based studies we quantitatively assessed studies using the I² statistic, and conducted random effects meta-analyses.
Study designs were heterogeneous with respect to populations, case definitions, and methods of ascertainment. Incidence of the studied comorbidities was rarely reported. Irritable bowel syndrome and chronic lung disease had a prevalence of more than 10% in the MS population. Irritable bowel syndrome, fibromyalgia, cataracts and glaucoma were more common than expected in the MS population.
Although they have been the subject of less study than other comorbidities, irritable bowel syndrome, arthritis, and chronic lung disease are common in the MS population and occur more often than expected when compared to the general population.
随着新的疾病修饰疗法的出现，我们需要更好地了解多发性硬化症（MS）中合并症的风险。
评估 MS 患者胃肠道、肌肉骨骼、眼部、肺部和肾脏合并症的发生率和患病率。
我们通过搜索 PUBMED、EMBASE、SCOPUS、Web of Knowledge 和检索文章的参考文献系统地审查了世界文献。对于选定的文章，一位评论员使用标准化表格摘录数据。第二位评论员对摘要进行了验证。我们评估了所有选定研究的质量。对于基于人群的研究，我们使用 I²统计量对研究进行了定量评估，并进行了随机效应荟萃分析。
研究设计在人群、病例定义和确定方法方面存在异质性。研究合并症的发生率很少有报道。肠易激综合征和慢性肺部疾病在 MS 人群中的患病率超过 10%。肠易激综合征、纤维肌痛、白内障和青光眼在 MS 人群中的发病率高于预期。
尽管与其他合并症相比，肠易激综合征、关节炎和慢性肺部疾病的研究较少，但它们在 MS 人群中很常见，与普通人群相比，其发病率高于预期。
