Bhatia Alka, Kumar Yashwant
Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Diagn Cytopathol. 2014 Feb;42(2):181-8. doi: 10.1002/dc.23012. Epub 2013 Jun 11.
Chromosomal instability (CIN) is the defining feature of most human cancers. The role of CIN has been suggested in diagnosis and prognostication of the tumors since long. However, the molecular methods used for its identification are costly, require expertise and may not be available in many of the laboratories. Therefore, this article tries to revisit the already described morphological indicators of CIN like multipolar mitoses, chromatin bridges, chromatin strings, nuclear heterogeneity, laggards, nuclear buds, micronuclei, and multinucleated micronucleated cells. The role of above as morphological biomarkers in diagnosis and prognosis of various cancers has been reviewed and the possibility of their inclusion in day to day reporting of malignancies is also discussed.
染色体不稳定（CIN）是大多数人类癌症的决定性特征。长期以来，CIN在肿瘤的诊断和预后评估中的作用已被提及。然而，用于识别CIN的分子方法成本高昂，需要专业知识，而且许多实验室可能无法采用。因此，本文试图重新审视已描述的CIN形态学指标，如多极有丝分裂、染色质桥、染色质丝、核异质性、落后染色体、核芽、微核和多核微核细胞。本文综述了上述指标作为形态学生物标志物在各种癌症诊断和预后中的作用，并讨论了将其纳入恶性肿瘤日常报告的可能性。
