EA 04-06, Control and Mechatronics Lab 1, Department of Mechanical Engineering, 9 Engineering Drive 1, National University of Singapore, Singapore 117576, Singapore.
Comput Methods Programs Biomed. 2013 Aug;111(2):347-56. doi: 10.1016/j.cmpb.2013.05.001. Epub 2013 Jun 10.
Closed-loop insulin delivery systems often implement glucose measurement and insulin administration in the subcutis. However some existing models for glucose-insulin system ignored the dynamics of subcutaneous glucose and subcutaneously-injected insulin. This paper reports a two-compartment model that includes glucose and insulin dynamics in subcutis, and its evaluation using patient data. Clinical information such as glucose level, insulin dosage, insulin injection time and meals of anonymous diabetes inpatients was collected. Measured glucose level of the diabetic inpatients agrees with that of computer simulation. Due to the lack of glucose-insulin model with subcutaneously-injected insulin for type 2 diabetic patients, our model was compared with existing model for type 1 subjects. The new glucose-insulin model can mimic dynamics of glucose and insulin under the disturbance of insulin injections and meals. Model parameters were estimated using nonlinear least square method and their effect on pathology and physiology of diabetes were analyzed.
闭环胰岛素输送系统通常在皮下组织中进行葡萄糖测量和胰岛素给药。然而，一些现有的葡萄糖-胰岛素系统模型忽略了皮下葡萄糖和皮下注射胰岛素的动力学。本文报告了一个包含皮下葡萄糖和胰岛素动力学的两室模型，并使用患者数据对其进行了评估。收集了匿名糖尿病住院患者的血糖水平、胰岛素剂量、胰岛素注射时间和膳食等临床信息。糖尿病住院患者的实测血糖水平与计算机模拟结果一致。由于缺乏用于 2 型糖尿病患者的皮下注射胰岛素的血糖-胰岛素模型，我们的模型与现有的 1 型患者模型进行了比较。新型血糖-胰岛素模型可以模拟胰岛素注射和膳食干扰下的葡萄糖和胰岛素动力学。使用非线性最小二乘法估计模型参数，并分析其对糖尿病病理生理学的影响。
