School of Psychology, University of Aberdeen, Aberdeen, UK.
Int J Psychophysiol. 2013 Jul;89(1):99-105. doi: 10.1016/j.ijpsycho.2013.05.019. Epub 2013 Jun 10.
Mu rhythm is an EEG measure of resting motor neurons, which is normally suppressed by input because of action observation or movement execution. This characteristic has caused mu suppression to be used as proxy marker for mirror neuron activation. However, there is little direct evidence that fluctuations in mu rhythm suppression reflect concurrent fluctuations in mirror neuron activity. A manual imitation paradigm was used to look at correlations between mu rhythm and BOLD response, by recording sequential EEG and fMRI measures to allow within-subject correlation analyses. Participants were instructed to imitate or observe actions involving the movement of a handle with their right hand. Mu power modulation, defined as mu power changes between conditions, correlated negatively with BOLD response in right inferior parietal lobe, premotor cortex and inferior frontal gyrus; putative mirror neuron areas. Clusters were also identified in bilateral cerebellum, left medial frontal gyrus, right temporal lobe and thalamus. This suggests that mu suppression involves a range of structures that modulate motor preparation activities and are sensitive to visual input, including but not restricted to the human analogue of the mirror neuron system.
mu 节律是一种用于测量静息运动神经元的 EEG 指标，正常情况下由于动作观察或运动执行，其会受到输入的抑制。这种特性使得 mu 抑制被用作镜像神经元激活的替代标志物。然而，很少有直接的证据表明 mu 节律抑制的波动反映了镜像神经元活动的波动。采用手动模仿范式，通过记录连续的 EEG 和 fMRI 测量值来进行相关分析，以研究 mu 节律与 BOLD 反应之间的相关性。参与者被要求用右手模仿或观察涉及手柄移动的动作。mu 功率调制定义为条件之间的 mu 功率变化，与右顶下小叶、运动前皮质和额下回的 BOLD 反应呈负相关；这些区域是假设的镜像神经元区域。还在双侧小脑、左内侧额回、右颞叶和丘脑上发现了簇。这表明 mu 抑制涉及一系列结构，这些结构调节运动准备活动，并且对视觉输入敏感，包括但不限于人类镜像神经元系统的类似物。
