Vivantes Humboldt-Klinikum Berlin, Department of Neurology, Stroke Unit, and Center for Epilepsy, Am Nordgraben 2, Berlin, Germany.
Epilepsy Behav. 2013 Jul;28 Suppl 1:S72-3. doi: 10.1016/j.yebeh.2013.02.019.
Following decades of neglect, there has been an increasing interest in the behavioral aspects of juvenile myoclonic epilepsy (JME) in the recent literature. A number of authors have investigated psychiatric comorbidity, cognitive profiles, and related behavioral features associated with JME. Although these findings are not entirely uniform, most studies suggest an increased incidence in psychiatric comorbidity and specific cognitive deficits that explain some of the clinical observations of poor compliance and other unhealthy behaviors in people suffering from JME. Neuropsychological profiles in JME are suggestive of subtle frontal dysfunctions, and some of the observations have been linked with sophisticated structural and functional imaging findings. Taken together, there is evidence that JME is associated with dysfunctions in networks linking motor and cognitive neuronal centers. Interestingly, there is evidence from family studies that the behavioral abnormalities in JME are genetically determined, suggesting an underlying developmental disorder.
在最近的文献中，人们对青少年肌阵挛性癫痫（JME）的行为方面越来越感兴趣。许多作者研究了与 JME 相关的精神共病、认知特征和相关行为特征。尽管这些发现并不完全一致，但大多数研究表明精神共病的发生率增加，以及特定的认知缺陷，这些缺陷可以解释 JME 患者中一些临床观察到的不遵医嘱和其他不健康行为。JME 的神经心理学特征提示存在轻微的额叶功能障碍，一些观察结果与复杂的结构和功能成像发现有关。总之，有证据表明 JME 与连接运动和认知神经元中心的网络功能障碍有关。有趣的是，来自家族研究的证据表明，JME 的行为异常是由遗传决定的，提示存在潜在的发育障碍。
