School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Neurology Department, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Behav Neurol. 2020 Sep 10;2020:8710373. doi: 10.1155/2020/8710373. eCollection 2020.
In this study, we aimed to evaluate the executive profile of juvenile myoclonic epilepsy (JME) patients using the Frontal Assessment Battery (FAB) as a bedside screening tool and investigate its association with seizure proximity, family history of epilepsy, and polytherapy/monotherapy with antiepileptic drugs (AEDs).
JME patients have deficits in various aspects of executive functions. FAB has proved to be a useful tool for evaluating executive functions in clinical settings.
Thirty-one JME patients and 110 healthy controls (HCs) were enrolled in this study. The participants were assessed using six subsets of FAB, including conceptualization, mental flexibility, motor programming, sensitivity to interference, inhibitory control, and environmental autonomy.
Compared to HCs, JME patients showed lower scores in conceptualization, mental flexibility, programming, sensitivity to interference, and total FAB. The number of AEDs (polytherapy versus monotherapy) and duration of time since the last seizure had no significant effect on FAB scores in JME patients. We found significant associations between disease duration and conceptualization, mental flexibility, inhibitory control, and total FAB score only in JME patients with recent seizure. Finally, receiver operating characteristic (ROC) analysis showed area under the curve (AUC) of 0.971 (95% confidence interval (CI): 0.947-0.994) for FAB total score, 0.933 for conceptualization (95% CI: 0.973-894), and 0.836 for mental flexibility (95% CI: 0.921-751).
In summary, JME patients had deficits in different aspects of executive functions. FAB is a useful clinical tool for evaluation of executive functions in JME patients.
本研究旨在使用额叶评估量表（FAB）作为床边筛查工具，评估青少年肌阵挛癫痫（JME）患者的执行功能特征，并探讨其与癫痫发作临近、癫痫家族史和抗癫痫药物（AED）的多药/单药治疗的关系。
JME 患者在执行功能的各个方面都存在缺陷。FAB 已被证明是评估临床环境中执行功能的有用工具。
本研究纳入了 31 名 JME 患者和 110 名健康对照者（HCs）。使用 FAB 的六个子集中评估参与者，包括概念化、思维灵活性、运动编程、对干扰的敏感性、抑制控制和环境自主性。
与 HCs 相比，JME 患者在概念化、思维灵活性、编程、对干扰的敏感性和总 FAB 得分方面的得分较低。AED 的数量（多药治疗与单药治疗）和上次癫痫发作后的时间间隔对 JME 患者的 FAB 评分没有显著影响。我们发现，仅在最近有癫痫发作的 JME 患者中，疾病持续时间与概念化、思维灵活性、抑制控制和总 FAB 评分之间存在显著相关性。最后，接受者操作特征（ROC）分析显示，FAB 总评分的曲线下面积（AUC）为 0.971（95%置信区间（CI）：0.947-0.994），概念化的 AUC 为 0.933（95% CI：0.973-894），思维灵活性的 AUC 为 0.836（95% CI：0.921-751）。
总之，JME 患者在执行功能的不同方面存在缺陷。FAB 是评估 JME 患者执行功能的有用临床工具。
