Snow B J, Peppard R F, Guttman M, Okada J, Martin W R, Steele J, Eisen A, Carr G, Schoenberg B, Calne D
Belzberg Laboratory of Clinical Neurosciences, Division of Neurology, University of British Columbia, Vancouver.
Arch Neurol. 1990 Aug;47(8):870-4. doi: 10.1001/archneur.1990.00530080052010.
We performed positron emission tomography using 18F-6-fluorodopa on four Guamanians with an amyotrophic lateral sclerosis syndrome, eight Guamanians with parkinsonism, and seven clinically normal Guamanians; the results were compared with those of nine Vancouver control subjects. The Guamanian subjects had all been exposed to similar Chamorro lifestyles. The scans were analyzed using a graphic method that calculates a constant for whole striatal 18F-6-fluorodopa uptake. The parkinsonian subjects all had significantly reduced striatal 18F-6-fluorodopa uptake. The group with amyotrophic lateral sclerosis had significantly reduced uptake that was intermediate between that of the control group and the parkinsonian group. Two Guamanian normal subjects had reduced striatal 18F-6-fluorodopa uptake. The nigrostriatal dopaminergic lesion in Guamanian parkinsonism is similar to that found in idiopathic parkinsonism. The nigrostriatal lesions in the subjects with amyotrophic lateral sclerosis and the Guamanian normal subjects are examples of subclinical neuronal damage demonstrable in living subjects with positron emission tomography.
我们对4名患有肌萎缩侧索硬化综合征的关岛人、8名患有帕金森症的关岛人以及7名临床正常的关岛人进行了18F - 6 - 氟多巴正电子发射断层扫描；并将结果与9名温哥华对照受试者的结果进行比较。这些关岛受试者都接触过相似的查莫罗生活方式。扫描结果采用一种图形方法进行分析，该方法可计算整个纹状体18F - 6 - 氟多巴摄取的一个常数。帕金森症受试者的纹状体18F - 6 - 氟多巴摄取均显著降低。肌萎缩侧索硬化组的摄取显著降低，介于对照组和帕金森症组之间。两名关岛正常受试者的纹状体18F - 6 - 氟多巴摄取降低。关岛帕金森症患者的黑质纹状体多巴胺能损伤与特发性帕金森症中发现的损伤相似。肌萎缩侧索硬化受试者和关岛正常受试者中的黑质纹状体损伤是在活体受试者中通过正电子发射断层扫描可显示的亚临床神经元损伤的实例。
