Gani D K, Mallineni S K, Emmadi P
Lenora Dental College, Department of Periodontology, Lenora Institute of Dental Sciences, Andhra Pradesh, India.
West Indian Med J. 2012 Nov;61(8):826-31.
The aim of the present study is to investigate systemic levels of inflammatory markers of cardiovascular diseases like C-reactive protein (CRP), interleukin-6 (IL-6), total leukocyte count and differential count in patients with chronic periodontitis, in comparison to healthy individuals without periodontal disease.
A total of 42 individuals, both males and females, above the age of 30 years, were included. Healthy controls (Group I, n = 14), patients with chronic localized periodontitis (Group II, n = 14) and chronic generalized periodontitis (Group III, n = 14), all without any other medical disorder were recruited and peripheral blood samples were taken. Serum samples of CRP and IL-6 were estimated by using different techniques. Total leukocyte count and differential count were estimated by standard clinical laboratory method.
Groups II and III had higher mean CRP levels than Group I (0.479, 0.544 versus 0.304 mg/dL). C-reactive protein level in Group III was statistically significant when compared to Group I (p = 0.04). Group III had higher median IL-6 level (6.35 pgm/ml) than Group II (< 5.0 pgm/ml) and Group I (< 5.0 pgm/ml). Median values of IL-6 were not statistically significant in any group (p = 0.29). Total leukocyte count was also elevated in Group III (10.4 x 10(3)/c.mm) compared to Group II and Group I (9.2 x 10(3)/c.mm and 7.9 x 10(3)/c.mm). This was statistically significant between different study groups (p < 0.0001). Neutrophil count in Group III was higher (68.0%) than Group II (62.4%) and Group I (57.4%). Neutrophil percentage was statistically significant in Group III, when compared to Group I (p = 0.0003).
Periodontitis results in higher systemic levels of CRP, IL-6, total leukocyte count and neutrophils. These elevated inflammatory factors may increase inflammatory activity in atherosclerotic lesions, potentially increasing the risk for cardiovascular events.
本研究旨在调查慢性牙周炎患者与无牙周疾病的健康个体相比，心血管疾病炎症标志物如C反应蛋白（CRP）、白细胞介素-6（IL-6）、白细胞总数及分类计数的全身水平。
共纳入42名年龄30岁以上的男女个体。招募了健康对照组（第一组，n = 14）、慢性局限性牙周炎患者（第二组，n = 14）和慢性广泛性牙周炎患者（第三组，n = 14），所有患者均无任何其他疾病，并采集外周血样本。采用不同技术检测CRP和IL-6的血清样本。通过标准临床实验室方法检测白细胞总数及分类计数。
第二组和第三组的平均CRP水平高于第一组（0.479、0.544对0. 304mg/dL）。与第一组相比，第三组的C反应蛋白水平具有统计学意义（p = 0.04）。第三组的IL-6中位数水平（6.35pgm/ml）高于第二组（<5.0pgm/ml）和第一组（<5.0pgm/ml）。IL-6的中位数在任何组中均无统计学意义（p = 0.29）。与第二组和第一组（9.2×10³/c.mm和7.9×10³/c.mm）相比，第三组的白细胞总数也升高（10.4×10³/c.mm）。不同研究组之间具有统计学意义（p < 0.0001）。第三组的中性粒细胞计数（68.0%）高于第二组（62.4%）和第一组（57.4%）。与第一组相比，第三组的中性粒细胞百分比具有统计学意义（p = 0.0003）。
牙周炎导致CRP、IL-6、白细胞总数和中性粒细胞的全身水平升高。这些升高的炎症因子可能会增加动脉粥样硬化病变中的炎症活性，潜在地增加心血管事件的风险。
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