Pejcić Ana, Kesić Ljiljana, Pesić Zoran, Mirković Dimitrije, Stojanović Mariola
Department of Periodontology and Oral Medicine, University of Nii, Serbia.
Acta Clin Croat. 2011 Jun;50(2):159-67.
Periodontal disease is considered to be an inflammatory disorder that is related to the accumulation of oral microbial biofilm and the host response to this accumulation. The host reaction to gingival microorganisms is characterized in part by increase in the polymorphonuclear leukocyte counts, which is one of the most important steps in host defense. Exaggerated leukocytes and neutrophils of host response are a very important component in the pathogenesis of periodontal disease. The purpose of this study was to investigate the relationship between white blood cell count and periodontal disease in subjects with moderate and severe periodontitis and in control subjects with healthy periodontal tissues. Leukocytes for the present study were obtained from peripheral venous blood of 50 patients with moderate periodontitis, 50 patients with severe periodontitis and 25 healthy subjects. The clinical parameters of periodontitis including plaque index, bleeding on probing and gingival index were determined in all study subjects. In both moderate and severe periodontitis, the results indicated a significantly higher count ofneutrophils (P < 0.001), as well as of both lymphocytes and total leukocytes (P < 0.05). The values of clinical parameters (plaque index, gingival index and bleeding on probing) also showed significant between-group differences (P < 0.005 and P < 0.001, respectively). It is possible that there is a significant relationship between total leukocyte count, neutrophil count and different forms of periodontal disease.
牙周病被认为是一种炎症性疾病，与口腔微生物生物膜的积累以及宿主对这种积累的反应有关。宿主对牙龈微生物的反应部分表现为多形核白细胞计数增加，这是宿主防御中最重要的步骤之一。宿主反应中过度的白细胞和中性粒细胞是牙周病发病机制的一个非常重要的组成部分。本研究的目的是调查中度和重度牙周炎患者以及牙周组织健康的对照受试者中白细胞计数与牙周病之间的关系。本研究中的白细胞取自50例中度牙周炎患者、50例重度牙周炎患者和25例健康受试者的外周静脉血。在所有研究对象中测定了牙周炎的临床参数，包括菌斑指数、探诊出血和牙龈指数。在中度和重度牙周炎中，结果均显示中性粒细胞计数显著更高（P < 0.001），淋巴细胞和白细胞总数也显著更高（P < 0.05）。临床参数值（菌斑指数、牙龈指数和探诊出血）在组间也显示出显著差异（分别为P < 0.005和P < 0.001）。白细胞总数、中性粒细胞计数与不同形式的牙周病之间可能存在显著关系。
