Husain Asif, Rashid Mohd, Mishra Ravinesh, Kumar Deepak
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard University, Hamdard Nagar, New Delhi-110062, India.
Acta Pol Pharm. 2013 May-Jun;70(3):443-9.
A series of bis-chalcones (3a-g) and their flavones derivatives (4a-g) were synthesized and evaluated for their antimicrobial activity. Bis-chalcones were prepared by condensing 1,1'-(4,6-dihydroxy-1,3-phenylene)diethanone (2) with appropriate aryl aldehydes following Claisen-Schmidt reaction conditions. Oxidative cyclization of bis-chalcones (3a-g) in DMSO in the presence of iodine furnished flavones (4a-g). The synthesized compounds were evaluated for their antibacterial and antifungal actions against some selected microbes. The results of antimicrobial evaluation showed that some of the synthesized compounds were good in their antibacterial and antifungal actions.
合成了一系列双查耳酮（3a - g）及其黄酮衍生物（4a - g），并对其抗菌活性进行了评估。双查耳酮是通过在克莱森 - 施密特反应条件下，使1,1'-（4,6 - 二羟基 - 1,3 - 亚苯基）二乙酮（2）与适当的芳醛缩合制备而成。双查耳酮（3a - g）在二甲基亚砜中于碘存在下进行氧化环化反应得到黄酮（4a - g）。对合成的化合物针对一些选定的微生物进行了抗菌和抗真菌作用评估。抗菌评估结果表明，一些合成化合物具有良好的抗菌和抗真菌作用。
