Siddiqui Leena, Hawsawi Mohammed B, Chotana Ghayoor Abbas, Saleem Rahman Shah Zaib
Department of Chemistry and Chemical Engineering, SBASSE, Lahore University of Management Sciences (LUMS), DHA, Lahore-54792, Pakistan.
Department of Chemistry, Faculty of Science, Umm Al-Qura University, Makkah 21955, Saudi Arabia.
ACS Omega. 2024 Sep 30;9(41):42061-42090. doi: 10.1021/acsomega.4c04635. eCollection 2024 Oct 15.
Originating from the basic chalcone structure, bis-chalcones are characterized by their dual ,-unsaturated carbonyl systems and carry a range of biological activities that include antimicrobial, antiviral, antiparasitic, antioxidant, antiproliferative, and chemical reactivities that warrant a review to cover recent progress. Thus, this review presents the significant potential demonstrated by bis-chalcones in various biological applications. For example, compounds showed excellent antiparasitic activity against leishmania with good selectivity index, and compounds - showed submicromolar activity against SupT1 cells. Compound stood out in its antiproliferative activity against a panel of 60 different cell lines. Compounds and have been shown as submicromolar noncompetitive xanthine oxidase inhibitors. We also present their recent applications in material science, for example, as photosensitizers and photoinitiators, to showcase their broader potential for innovation in both medicinal chemistry and industrial applications.
双查耳酮起源于基本的查耳酮结构，其特点是具有双α,β-不饱和羰基系统，并具有一系列生物活性，包括抗菌、抗病毒、抗寄生虫、抗氧化、抗增殖以及化学反应活性，这些都值得进行综述以涵盖最新进展。因此，本综述展示了双查耳酮在各种生物应用中所展现的巨大潜力。例如，化合物对利什曼原虫表现出优异的抗寄生虫活性，且选择性指数良好，化合物对SupT1细胞表现出亚微摩尔活性。化合物在针对60种不同细胞系的抗增殖活性方面表现突出。化合物和已被证明是亚微摩尔级的非竞争性黄嘌呤氧化酶抑制剂。我们还介绍了它们在材料科学中的最新应用，例如作为光敏剂和光引发剂，以展示它们在药物化学和工业应用中更广泛的创新潜力。
